Beatriz Achon Buil

Abstract Stroke remains a leading cause of disability due to the brain’s limited ability to regenerate damaged neural circuits. Here, we show that local transplantation of iPSC-derived neural progenitor cells (NPCs) improves brain repair and long-term functional recovery in stroke-injured mice.

1 Introduction Stroke remains a leading cause of disability and death worldwide with no regenerative treatments available.[1] Current acute treatments, such as intravenous thrombolysis (tPA) and mechanical thrombectomy, must be administered within a critical short time window and are not applicable for many patients.[2, 3] Stem cell therapy is considered one of the most promising experimental strategies for enhancing stroke recovery beyond this acute window, as transplanted cells have the...

Abstract Neural stem cell therapies hold great promise for improving stroke recovery, but the hostile stroke microenvironment can hinder the initial graft survival. It has long been well documented that the microenvironment evolves over time, making it crucial to identify the optimal transplantation window to maximize therapeutic efficacy. However, it remains uncertain whether acute or delayed local cell transplantations better supports graft viability after stroke.