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Editor’s summary HNRNPH1 and HNRNPH2 are closely related RNA binding proteins with similar roles in RNA processing and splicing during neurogenesis. De novo mutations in the HNRNPH2 gene cause a rare and severe neurodevelopmental disorder for which there is currently no treatment. Here, Korff et al. designed gapmer antisense oligonucleotides (ASOs) to target Hnrnph2 and show that a knockdown of Hnrnph2 mRNA up-regulated Hnrnph1 mRNA and protein.
Keywords oligodendrocyte maturation differentiation development myelin multiple sclerosis epigenetic Sox6 Get full text access Log in, subscribe or purchase for full access. References 1. Alvarez-Dominguez, J.R. ∙ Melton, D.A. Cell maturation: Hallmarks, triggers, and manipulation Cell. 2022; 185:235-249 2. Karbassi, E. ∙ Fenix, A. ∙ Marchiano, S. ... Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine Nat. Rev. Cardiol. 2020; 17:341-359 3. Kook, H.
Tracy L. Hagemann https://orcid.org/0000-0002-0237-9267 , Berit Powers, Ni-Hsuan Lin https://orcid.org/0000-0003-4524-3615, Ahmed F. Mohamed, Katerina L. Dague https://orcid.org/0000-0001-5613-9018, Seth C. Hannah, Gemma Bachmann https://orcid.org/0000-0002-3974-191X, … Show All … , Curt Mazur https://orcid.org/0000-0003-3485-9086, Frank Rigo, Abby L. Olsen https://orcid.org/0000-0002-7680-1758, Mel B.
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