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Billy Jebaraj on Muck Rack

Billy Jebaraj

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Articles

The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemia

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By Cristina Lopez Verified, Cristina Sen López, Nnamdi Okeke, Christoph Wiegreffe, Susanne Bens, Emil Chteinberg, Barbara Eichhorst, Martin Dyer, Anja Fischer, Kirsten Fischer, Selina Glaser, Michael Hallek, Helene Kretzmer, Anja Mottok, Jan P. Meier-Kolthoff, Matthias Schlesner, Christof Schneider, Stefan Britsch, Ole Ammerpohl, Stephan Stilgenbauer, Eugen Tausch, Reiner Siebert, Cosima Drewes, Billy Jebaraj, Isabelle Kraus, Sina Hillebrecht, Amani Awada, Sarah Datismann, Dominick Pfaff, Karoline Schnitzler
| Nature Verified
Abstract Activation of oncogenes by hijacking immunoglobulin gene loci (IG) enhancers via chromosomal translocation is a common pathogenetic mechanism in B-cell malignancies, affecting 5–10% of chronic lymphocytic leukemia (CLL). The oncogenic partners in many of these cases remain unidentified. Therefore, we conducted a comprehensive analysis of 144 CLL samples with IGH-translocation excluding IGH::BCL2, IGH::CCND1, IGH::BCL3 and IGH::MYC.
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