Martin Dyer

Abstract Activation of oncogenes by hijacking immunoglobulin gene loci (IG) enhancers via chromosomal translocation is a common pathogenetic mechanism in B-cell malignancies, affecting 5–10% of chronic lymphocytic leukemia (CLL). The oncogenic partners in many of these cases remain unidentified. Therefore, we conducted a comprehensive analysis of 144 CLL samples with IGH-translocation excluding IGH::BCL2, IGH::CCND1, IGH::BCL3 and IGH::MYC.

Abstract It took decades from the discovery of BCL-2, initially identified in chromosomal translocations associated with lymphoid malignancies, to understand how BCL-2 and its family members regulate apoptosis, launching a transformative journey in cancer biology often called “the road to ruin”. Developing powerful BCL-2 inhibitors for clinical use required decades. Yet, this remains as one of the most successful achievements in a field that started ~40 years ago, as recounted by its pioneers.

The switch chain is a well-studied Markov chain which generates random graphs with a given degree sequence and has uniform stationary distribution. Motivated by the high number of triangles seen in some real-world networks, we study a variant of the switch chain, which is more likely to produce graphs with higher numbers of triangles.