Bingying Wang
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A genetically encoded sensor of ionic stress links cellular proton dynamics to sleep
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Although biosensors for specific cellular ions are widely available, real-time monitoring of overall ionic strength in living organisms remains challenging.
A conserved antioxidant defense at the endoplasmic reticulum membrane
Keywords ERGU-1 TMEM161B ER redox homeostasis hydrogen peroxide antioxidant defense oxidative protein folding AlphaFold2 ER membrane proteostasis conserved transmembrane oxidoreductase SKN-1/NRF2 signaling Research topic(s) CP: molecular biology Introduction In eukaryotic cells, the endoplasmic reticulum (ER) plays a critical role in protein folding, a process essential for cell function but one that generates the reactive oxygen species hydrogen peroxide (H2O2).1,2,3 The ER-residing oxidase...
Induction and regulation of reversible suspended animation in C. elegans
Abstract Suspended animation, a state of profound metabolic, behavioral and developmental quiescence, is a remarkable yet poorly understood stress resilience strategy in animals. Here, we describe a previously uncharacterized form of suspended animation inducible by high-population density in isosmotic liquids in C. elegans throughout larval development and adulthood.
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