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Articles

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

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By Tomer Zohar, Stephanie Fischinger, Caroline Atyeo, Chuangqi Wang, Matthew D. Slein, John Burke, Jingyou Yu, Jared Feldman, Aaron Schmidt Verified, Yongfei Cai, Hendrik Streeck, Edward Ryan, Dan Barouch, Blake Marie Hauser, Tim Caradonna
| ScienceDirect Verified
Highlights • IgA and IgM evolve rapidly across all levels of disease severity • Rapid and potent IgG class switching is linked to survival • Moderate disease is associated with a delay but ultimate convergence of IgG • Early S2-cross-reactivity is linked to survival after severe disease Summary The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress in the absence of well-defined correlates of immunity.
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