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Bob Lin

As seen in: Nature, Science Magazine, Cell Press, Cell Reports, Paint and Coatings Industry
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Articles by Bob Lin

Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants

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By Timothy Johnston, Shuk Hang Li, Mark Painter, Divya Swaminathan, Reilly K. Atkinson, Bernadeta Dadonaite, Shuishu Wang, Naomi R. Douek, Lucas Kampman, Rachel Kazmierski, Bob Lin, Leonid Serebryannyy, Haijuan Du, Amy Henry, Sarah Smith, Farida Laboune, I-Ting Teng, Lingshu Wang, Nicole A. Doria-Rose, Chaim A. Schramm, Theodore C. Pierson, Tongqing Zhou, Jesse Bloom, E. John Wherry, Scott Hensley Verified, Daniel Douek, Robin Schlesinger
| Nature Verified
Abstract For rapidly mutating viruses such as influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune memory recalled by antigenically drifted variants primarily comprises antibodies that cross-react to the priming strain rather than de novo elicited responses, a phenomenon termed original antigenic sin or immune imprinting. The composition and functionality of de novo responses elicited by variant exposures remain unclear.
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SARS-CoV-2 variant booster vaccination and infection alter the breadth of the memory B cell repertoire

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By Kyeongseok Jeon, Axel A Guzmán-Solís, Rory Malek, Flávio Lemos Matassoli, Kyle Gordon, Geoffrey D. Shimberg, Grace Mantus, Abby Spangler, Ankita J. Chopde, I-Ting Teng, Tongqing Zhou, Bob Lin, Robin Carroll, Rachel Kazmierski, Lingshu Wang, Christine M. Posavad, Nadine Rouphael, Angela R. Branche, Paul Roberts, Leonid Serebryannyy, Sarah Andrews
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary As SARS-CoV-2 continues to evolve in response to vaccine- and infection-induced immune pressure, vaccines will need to be updated to match currently circulating strains. Here, Malek et al. evaluated what impact a SARS-CoV-2 Omicron variant booster vaccine had on the overall memory B cell (MBC) response to SARS-CoV-2.
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VRC01 with antiretroviral initiation in infants is well tolerated, and higher concentrations associate with greater HIV-1 DNA declines

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By Alka Khaitan, David R. Ziehr, PING LIU, Jane Lindsey, Edmund V. Capparelli, Camlin Tierney, Anne Coletti, Charlotte Perlowski, Dwight E. Yin, Hans Spiegel, Sai Majji, Jack Moye, Lúcio Gama, Richard A. Koup, Bob Lin, Adrian McDermott, Paul Harding, Mark F Cotton, Diane Costello, Christos Petropoulos, Jacqueline Reeves, Rachel Chihana, Lynette Purdue, Chelsea Krotje, Macpherson Mallewa
| Science Magazine Verified
Editor’s summary Although broadly neutralizing antibodies (bNAbs) have shown promise as both a prophylactic and therapeutic agent for HIV-1, most of the clinical studies in this area have recruited adult participants. To ask whether bNAbs might be effective at controlling HIV-1 in infants, Khaitan et al. conducted a clinical trial recruiting infants with HIV-1 who initiated antiretroviral therapy (ART) within the previous 14 days.
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SARS-CoV-2 vaccination and infection elicit cross-neutralizing responses against clade 3 and 4 sarbecoviruses

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By Stephen Schmidt Verified, Rahul Subramanian, Robin Carroll, Megi Rexhepaj, Jeffrey Liao, Jennifer A Bohl, Ananda Chowdhury, Alicen B Spaulding, Bob Lin, Mike Castro, Richard A. Koup, Leonid Serebryannyy, Daniel Douek, Manjula Basappa, Christine M. Posavad
| Nature Verified
Abstract Two sarbecoviruses, SARS-CoV-1 and SARS-CoV-2 that engage ACE2 through their receptor-binding domains, have caused major human outbreaks. The pandemic potential of sarbecoviruses has prompted the discovery and classification of bat and other zoonotic sarbecoviruses that are also able to use human ACE2 or ACE2 ortholog receptors for infection. However, the current human immunological landscape reactive to these SARS-CoV-2-related viruses is not well profiled.
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Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection

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By Lela Kardava, James Lim, Clarisa M. Buckner, Xiaozhen Zhang, Wei Wang, Omar El Merhebi, Krittin Trihemasava, I-Ting Teng, Robin Carroll, Yogita Jethmalani, Mike Castro, Bob Lin, Lauren Praiss, Catherine Seamon, Peter D. Kwong, Richard A. Koup, David Nickle, Tae-Wook Chun, Susan Moir, Mattie L. Melnyk, Leonid Serebryannyy
| Cell Reports Verified
Keywords B cells adaptive immune memory antibodies SARS-CoV-2 COVID-19 mRNA vaccines booster vaccination breakthrough infection hybrid immunity Research topic(s) CP: Immunology Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-encoding mRNA vaccines were developed shortly after the emergence of COVID-19 and shown to protect through the induction of potent neutralizing antibodies against the viral protein.1,2,3 The primary two-dose mRNA vaccine was also found to...
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Novel Approaches to Improve Scratch and Abrasion Resistance in UV Coatings

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By Marco Heuer, Bob Lin, Maria Nargiello, Roger Reinartz
| Paint and Coatings Industry Verified
As UV coatings continue to be applied to a broader range of substrates, the demand for scratch and abrasion resistance continues to grow. This is especially true with thin-film applications over flexible, semi-porous or hard substrates with varying types of gloss or haptic properties. There are a variety of ways in which damage can occur due to various geometries and forces of the objects scraping over the coating surfaces.
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