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Articles by Bowen Chen
Dual-Mode Optical Temperature Sensing of Mg 0.75 Al 2.16 O 4 : Cr 3 + /Er 3 + Transparent Ceramic With Spatial Separation Structure
Conflicts of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Data Availability Statement Research data are not shared. Supporting Information Filename Description jace71343-sup-0001-SupMat.docx594.2 KB Supporting File: jace71343-sup-0001-SupMat.docx.
Oxide–Oxide Interactions Dominating the Reaction Pathways in CO 2 -Assisted Oxidative Dehydrogenation of Ethane
1 Introduction Ethylene, a core platform compound in the petrochemical industry, serves as a key foundational raw material for manufacturing bulk chemicals [1-3]. Ethane dehydrogenation has attracted considerable attention as a route for ethylene production, driven by the abundant availability of shale gas feedstocks and offering lower energy consumption and reduced carbon emissions compared to traditional naphtha cracking or coal-to-olefin processes [4].
Oxide–Oxide Interactions Dominating the Reaction Pathways in CO 2 -Assisted Oxidative Dehydrogenation of Ethane
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description ange75317-sup-0001-SuppMat.pdf10 MB Supporting File: ange75317-sup-0001-SuppMat.pdf.
Engineered Transformer Base Editor with Enhanced Editing Efficiency
1 Introduction The CRISPR-Cas systems, such as Type II Cas9 [1] and Type V Cas12 [2], are widely used for gene knockout and homology-directed repair. However, the DNA double-strand breaks (DSBs) induced by the nucleases can trigger undesirable cellular events, including p53-mediated DNA damage responses [3, 4], large fragment deletions [5, 6], and chromothripsis [7].
Single-cell transcriptomic profiling reveals distinct vascular-associated microglia signatures in cerebral small vessel disease
Abstract Cerebral small vessel disease (CSVD) is a major cause of cognitive impairment, characterized by neuroinflammation and microvascular dysfunction. A specialized subset of microglia, known as vascular-associated microglia (VAM), intimately interacts with the cerebral vasculature and plays a pivotal role in mediating neuroinflammation originating from the vasculature.
High-speed and stable 532-nm electro-optic modulator on thin-film lithium tantalate
We demonstrate a high-speed, DC-bias-stable Mach–Zehnder electro-optic modulator at 532 nm on a thin-film lithium tantalate on insulator (LTOI) platform.
Proof of Work: What If We Hired Engineers the Way Open Source Already Works? So I Tried Building a Platform for It
Part 1 of a series on building Builders’ Echo as a solo founder— a proof-of-work contest marketplace for technical hiring Press enter or click to view image in full size Photo by Anthony Riera on Unsplash There’s a strange gap at the heart of how we hire engineers. The job itself is building things. But hiring for it barely involves building anything. We ask people to whiteboard algorithms they’ll rarely touch again.
Light hydrogen isotopes in terrestrial core
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The origin of Earth’s water remains unresolved. Hydrogen isotopes provide a key tracer of planetary water history, yet the isotope composition of Earth’s core—the planet’s largest internal reservoir—has remained unconstrained.
Enhancing the Transparency of Y 3 Ga 5 O 12 Ceramics via GeO 2 -Assisted Tailoring of Sintering Kinetics and Microstructure
1 Introduction Similar to Y3Al5O12 (YAG), Y3Ga5O12 (YGG) is a classic garnet-type material, rendering it suitable for doping with both rare earth ions and transition metal ions. YAG has been widely used in white light-emitting diodes and laser gain media. By contrast, YGG exhibits a lower conduction band energy and abundant intrinsic traps formed by the considerable lattice defects induced by activator ions [1].
Assessment of Papillary Thyroid Carcinoma by Profiling Multiple Matrix Metalloproteinase Activities Using a Machine Learning-Assisted Peptide Microarray Sensing Platform Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJune 29, 2026 Assessment of Papillary Thyroid Carcinoma by Profiling Multiple Matrix Metalloproteinase Activities Using a Machine Learning-Assisted Peptide Microarray Sensing Platform Click to copy article linkArticle link copied! Zhenshengnan Li Zhenshengnan Li Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China Xudong Sun Xudong Sun Key Laboratory of Electroanalytical Chemistry,...
Apatinib inhibits synovial sarcoma progression and angiogenesis via VEGFR2-mediated AKT/FOXO3A and ERK1/2/FOXM1 signaling pathways
Abstract Synovial sarcoma (SS) is a highly aggressive soft-tissue malignancy with limited therapeutic options for advanced disease. Here, we report that apatinib, a selective VEGFR2 tyrosine kinase inhibitor, exerts potent antitumor and anti-angiogenic activity in SS. In SS cell lines, apatinib reduced cell viability, induced G1 phase arrest, and triggered both apoptosis and autophagy.
Diurnal Patterns of Accelerometer-Measured Physical Activity and Sleep in Relation to Cancer Risk: Findings From a Nationally Representative Study
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Researchers can request the data used for the analysis from the NHANES (https://www.cdc.gov/nchs/nhanes/index.htm). All source code is publicly available on GitHub (https://github.com/garic019/IJC-25-3844). The original contributions presented in the study are included in the article/ further inquiries can be directed to the corresponding author.
CellVoyager: AI CompBio agent generates new insights by autonomously analyzing biological data
Abstract Modern biology increasingly relies on complex, high-dimensional datasets such as single-cell RNA sequencing (scRNA-seq), which present a vast space of potential hypotheses. Systematically exploring this space is often impractical, as scRNA-seq analyses are time-consuming and require substantial computational and domain expertise.
High-resolution grayscale printing on Ge thin films via two-beam direct laser writing
Grayscale lithography is crucial for micro-optical component fabrication but faces challenges in resolution and cost. Conventional methods are diffraction-limited, while phase-change materials often require complex processing. This work presents germanium (Ge) thin films as a versatile platform for maskless grayscale printing. A custom dual-beam direct laser writing system is developed, using a 450 nm auxiliary laser for localized preheating and a 405 nm writing beam for patterning.
Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults
Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults Supplement 1. eFigure 1. Overview of study design and key analyses eFigure 2. Flowchart of the included population eTable 1. Baseline characteristics of included and excluded participants eTable 2. Questionnaire items and responses of each ACEs and AAEs indicator eFigure 3. Distribution of item-response probabilities across latent classes of ACEs eFigure 4.
Characterising symptom clusters: examining profiles of somatic symptoms and their psychosocial predictors among chinese youths using longitudinal data with a machine learning approach
Abstract Objective Somatic symptoms (SS) pose public health burdens, but it remains unclear whether SS should be defined by overall severity or specific symptoms. Therefore, we aimed to identify SS profiles and explore how psychosocial predictors shape these profiles based on the biopsychosocial model. Methods and measures From October to December 2020, Chinese college students (n = 598) completed three waves of survey on SS and psychosocial predictors.
The ε-Fe2C/Cu Interface Synergistically Boosts Highly Selective Fischer–Tropsch Synthesis toward Light Olefins
Energy, Environmental, and Catalysis ApplicationsJanuary 6, 2026 Yongting Li State Key Laboratory of Coordination Chemistry, Key Lab of Mesoscopic Chemistry MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Chenyang Shen State Key Laboratory of Coordination Chemistry, Key Lab of Mesoscopic Chemistry MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Bowen Chen State Key Laboratory of Coordination Chemistry,...
Phase evolution of MgAlON in the pressureless presintering and its influence on the fabrication of transparent ceramics
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Synthesis of novel multi‐anion Hf0.8Zr0.2B0.1C0.5N0.4 powder
REFERENCES 1, , , , , , et al. Advances in ultra-high temperature ceramics, composites, and coatings. J Adv Ceram. 2022; 11(1): 1–56. 2, , , , . Ultra-high temperature ceramics for extreme environments. Nat Rev Mater. 2024; 9(11): 773–789. 3, , . Research progress of high-entropy carbide ultra-high temperature ceramics. J Inorg Mater. 2024; 39(6): 591–608. 4, , , , . Research progress on ultra-high temperature ceramic composites. J Inorg Mater 2024; 39(6): 571–590. 5.
Coming Clean and Avoiding Bubble Trouble - Using Detergents Wisely in the Purification of Membrane Proteins for Cryo-EM Studies
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Clearance of protein aggregates during cell division
eLife Assessment How misfolded proteins are segregated and cleared is a significant question in cell biology, since clearance of these aggregates can protect against pathologies that may otherwise arise. The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the anaphase promoting complex (APC).
Fabrication and characterization of the MgGa2O4 transparent ceramic with multicolor persistent luminescence
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description jace70013-sup-0001-SuppMat.docx1 MB Supporting information REFERENCES 1, , , , , , et al. Bright and persistent green emitting MgGa2O4:Mn2+ for phosphor converted white light emitting diodes. Dalton T. 2025; 54(3): 1038–1051. https://doi.org/10.1039/D4DT02960G 2, , , , , .
Stack-based multilayer optical storage devices with sodium silicate as bonding layers
Textual information is essential for the inheritance of human civilization; it is important to find a suitable way to preserve it. Existing information storage methods face limitations in meeting the demands of large capacity and long-term preservation of textual information. To solve these problems, this study proposes a stacked-based multilayer optical storage device utilizing laser heat-mode photoresist as recording media.
Solid‐Liquid Interfacial Hydrogen Bond Mediated Mass Transfer toward Industrial Water Electrolysis
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
The Media Spatial Diffusion Effect and Distribution Characteristics of AI in Education: An Empirical Analysis of Public Sentiments Across Provincial Regions in China
1. Introduction The application of artificial intelligence (AI) technology in the field of education is currently undergoing rapid development. AI, through intelligent sensing, teaching algorithms, and data-driven decision-making, enables automated analysis and precise interventions for learners, teachers, and educational content. It provides timely and personalized guidance and feedback, supporting and fulfilling educational and learning needs.
Ti3C2Tx‐Based Cross‐Scale Laminated Structural Structures: Enabling Sub‐Wavelength Impedance Modulation and Underwater Broadband Sound Absorption
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202411347-sup-0001-SuppMat.docx1.7 MB Supporting Information References 1a) , , , Sci. Rep. 2023, 13, 7983; b) , , , , Appl. Phys. Lett. 2021, 118, 071904; c) , , , , , , , Sci. Adv. 2022, 8, 4206; d) , , , , Phys. Rev. Appl. 2022, 18, 044008. 2a) , , , , Polym. Test. 2021, 96, 107115; b) , , , Eng. Rep. 2023, 5, e12627.
Paper page - OctoTools: An Agentic Framework with Extensible Tools for Complex Reasoning
Papers Published on Feb 16 · Submitted by lupantech on Feb 19 Abstract Solving complex reasoning tasks may involve visual understanding, domain knowledge retrieval, numerical calculation, and multi-step reasoning. Existing methods augment large language models (LLMs) with external tools but are restricted to specialized domains, limited tool types, or require additional training data.
Cooperative Magnetic Interfacial Microrobot Couple for Versatile Non‐Contact Biomedical Applications
Conflict of Interest The authors declare no conflict of interest.
Cooperative Magnetic Interfacial Microrobot Couplefor Versatile Non‐Contact Biomedical Applications
Conflict of Interest The authors declare no conflict of interest.
Study on the Mechanical Properties, Tensile Performance, Hydration Heat, and Microstructure of VAE-Modified Rubber Mortar
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Wavelength Conversion Process of Intra-Pulse Stimulated Raman Scattering in Near-Zero Negative Dispersion Range
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METTL3 and FTO Regulate Heat Stress Response in Hu Sheep Through Lipid Metabolism via m6A Modification
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Impact Mechanism of Negative Academic Emotions on Academic Procrastination: The Mediating and Moderating Roles of Self-Efficacy and Goal Orientation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
In Situ-Grown Ultrathin Catalyst Layers for Improving both Proton Exchange Membrane Fuel Cell and Anion Exchange Membrane Fuel Cell Performances
Energy, Environmental, and Catalysis ApplicationsJuly 30, 2024 Dongyue Xin State Key Lab of Organic−Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Xuerui Liu State Key Lab of Organic−Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Bowen Chen State Key Lab of...
IJGI | Free Full-Text | Research on the Spatial Distribution Characteristics and Influencing Factors of Educational Facilities Based on POI Data: A Case Study of the Guangdong-Hong Kong-Macao Greater Bay Area
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Bayesian Statistical Inference for Factor Analysis Models with Clustered Data
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
[2405.18205] Joint Radar Sensing, Location, and Communication Resources Optimization in 6G Network
[Submitted on 28 May 2024] Title:Joint Radar Sensing, Location, and Communication Resources Optimization in 6G Network View a PDF of the paper titled Joint Radar Sensing, Location, and Communication Resources Optimization in 6G Network, by Haijun Zhang and 3 other authors View PDF HTML (experimental) Abstract:The possibility of jointly optimizing location sensing and communication resources, facilitated by the existence of communication and sensing spectrum sharing, is what promotes the...
Dilute RuCo Alloy Synergizing Single Ru and Co Atoms as Efficient and CO‐Resistant Anode Catalyst for Anion Exchange Membrane Fuel Cells
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Generation of Different Mode-Locked States in Nonlinear Multimodal Interference-Based Fiber Lasers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Clearance of protein aggregates during cell division
Abstract Protein aggregates are spatially organized and regulated in cells to prevent deleterious effects of proteostatic stress. Misfolding of proteins in the ER result in aggregate formation, but how the aggregates are processed especially during cell division is not well understood. Here, we induced proteostatic stress and protein aggregation using a proteostasis reporter, which is prone to misfolding and aggregation in the ER.
Medieval DNA from Soqotra points to Eurasian origins of an isolated population at the crossroads of Africa and Arabia - Nature Ecology & Evolution
Abstract Soqotra, an island situated at the mouth of the Gulf of Aden in the northwest Indian Ocean between Africa and Arabia, is home to ~60,000 people subsisting through fishing and semi-nomadic pastoralism who speak a Modern South Arabian language. Most of what is known about Soqotri history derives from writings of foreign travellers who provided little detail about local people, and the geographic origins and genetic affinities of early Soqotri people has not yet been investigated directly.
Applied Sciences | Free Full-Text | Research on the Spatial and Temporal Distribution Evolution and Sustainable Development Mechanism of Smart Health and Elderly Care Demonstration Bases Based on GIS
1. Introduction In the traditional fabric of Chinese society, families were originally the primary caretakers for elderly individuals. However, as social industrialization and urbanization have deepened, there has been a widening gulf between urban and rural areas in terms of living standards and income levels. This has resulted in a marked increase in population mobility.
Extended Kohler's rule of magnetoresistance in ${\mathrm{TaCo}}_{2}{\mathrm{Te}}_{2}$
TaCo2Te2 is recently reported to be an air-stable, high mobility van der Waals material with probable magnetic order. Here we investigate the scaling behavior of its magnetoresistance.
Improvement of Li-ion conductivity and air stability of Ta-doped Li7La3Zr2O12 electrolyte via Ga co-doping and its application in Li-S battery
Improvement of Li-ion conductivity and air stability of Ta-doped Li7La3Zr2O12 electrolyte via Ga co-doping and its application in Li-S battery The garnet-type solid electrolyte Li7La3Zr2O12 (LLZO) has emerged as a promising candidate for all-solid-state lithium-ion batteries (ASSLBs) due to its exceptional performance. However, it currently faces challenges related to low ionic conductivity and structural instability, which limit its widespread application.
Trajectories and determinants of acute stress disorder during the COVID‐19 centralized quarantine: A latent class growth analysis
CONFLICT OF INTEREST STATEMENT The authors have no competing interests to declare. Supporting Information Filename Description smi3351-sup-0001-suppl-data.docx55.3 KB Supporting Information S1 REFERENCES American Psychiatric Association. (2022). Trauma- and stressor-related disorders. In Diagnostic and statistical manual of mental disorders ( 5th ed.).
Identification of Dynamic Vibration Parameters of Partial Interaction Composite Beam Bridges Using Moving Vehicle
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Electroacupuncture promotes the repair of the damaged spinal cord in mice by mediating neurocan‐perineuronal net
1 INTRODUCTION Spinal cord injury (SCI) is followed by spontaneous anatomical and functional recombination of neural circuits at multiple levels of the nerve axis,1 and the environmental factors affecting the damaged nervous system are diverse and complex. Compensatory responses such as neural tissue protection and endogenous repair and arousal after spinal cord injury are limited, which are insufficient to support complete functional recovery.
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