Brian Cleary on Muck Rack

Brian Cleary

Charleston
As seen in: Nature, Archives of Disease in Childhood, Ars Technica, BMJ Open, European Journal of Hospital Pharmacy, MDPI, SAGE Publishing, Sports Illustrated, Science Magazine, InformationWeek and
Happily married radio programmer trying to suceed in an ever changing industry I love. The end goal - make some people happy and make even a small difference
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Articles

Accurate trajectory inference in time-series spatial transcriptomics with structurally-constrained optimal transport

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By John Bryan, Samouil L. Farhi, Brian Cleary
| Nature Verified
Abstract New experimental and computational methods use genetic or gene expression observations with single cell resolution to study the relationship between single-cell molecular profiles and developmental trajectories. Most tissues contain spatially contiguous regions that develop as a unit, such as follicles in the ovary, or tubules and glomeruli in the kidney.
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Accurate trajectory inference in time-series spatial transcriptomics with structurally-constrained optimal transport

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By John Bryan, Samouil L. Farhi, Brian Cleary
| BioRxiv
Abstract New experimental and computational methods use genetic or gene expression observations with single cell resolution to study the relationship between single-cell molecular profiles and developmental trajectories. Most tissues contain spatially contiguous regions that develop as a unit, such as follicles in the ovary, or tubules and glomeruli in the kidney.
Open in Who Shared Issue with article?

Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

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By Aiping Jiang, Serwah Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T. Manguso, Kathleen B. Yates, Ralda Nehme, Brian Cleary, Samouil L. Farhi
| Cell Press Verified
Keywords pooled CRISPR screen spatial transcriptomics single-cell perturbations multimodal screening pooled optical profiling Introduction Pooled loss-of-function screening has proven to be a powerful application of CRISPR-Cas9 technology, identifying the genetic underpinning of phenotypes such as enhanced growth,1 drug resistances,2 and virus infection rates.3 The scalable experimental workflow of pooled guide RNA (gRNA) cloning, lentiviral packaging, and subsequent sequencing-based gRNA...
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