Article Sidebar Published: Aug 11, 2025 Keywords: sonic hedgehog, orofacial clefting, smoothened receptor, adverse outcome pathway (AOP), new approach methodologies (NAMs) Main Article Content Abstract Article Details Reynolds, J. I. and Johnson, B. P. (2025) “AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting”, ALTEX - Alternatives to animal experimentation. doi: 10.14573/altex.2407121. Articles Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional...