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Buyao Li

As seen in: BioRxiv, Cell Reports Medicine
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Articles

Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging

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By Zihan Zhang, Bin Ma, Bin Guo Ma, Buyao Li, Zhiwei Li, Min Gao, Hailong Zhao, Rui Peng, Jiang Hu, Yu Wang, Wei You, Xun Gui, Rui Wang, Xiaoqing Hu, Beidi Chen, Yuanjie Zhang, yanyun Hao, Xiaolin Sun, Liang Zhang, Ming Lu, Demin Zhou, Yun Yang, Mi Deng, Lei Miao, Peishi Rao
| Cell Reports Medicine Verified
Keywords chimeric antigen receptor: CAR circular mRNA T cells uPAR senolytic aging-inflamed disorders Introduction Over the past several decades, chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of previously incurable hematological malignancies, including lymphoma, leukemia, and multiple myeloma.1 The remarkable specificity and potent cytotoxicity of CAR-T cells have sparked interest in exploring non-cancer applications, though their clinical utility remains...
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Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in-vivo CAR-T therapy for inflamm-aging

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By ZIHAN ZHANG, Bin Ma, Bin Guo Ma, Zhiwei Li, Buyao Li
| BioRxiv
Abstract mRNA-based in vivo CAR T cell engineering offers advantages over ex vivo therapies, including streamlined manufacturing and transient expression. However, current delivery requires antibody-modified vehicles with manufacturing challenges. In this study, inspired by cardiolipin, we identified a cardiolipin-like di-phosphoramide lipid that improved T cell transfection without targeting ligands, both in vivo and in vitro.
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