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Byersdorfer C.A

As seen in: Cell Reports, The Journal of Biological Chemistry
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Articles

Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function

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By Craig A. Byersdorfer, Byersdorfer C.A, Erica Braverman, Cellular Therapies
| The Journal of Biological Chemistry Verified
Abstract Cellular therapies are currently employed to treat a variety of disease processes. For T cell-based therapies, success often relies on the metabolic fitness of the T cell product, where cells with enhanced metabolic capacity demonstrate improved in vivo efficacy. AMP-activated protein kinase (AMPK) is a cellular energy sensor which combines environmental signals with cellular energy status to enforce efficient and flexible metabolic programming.
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Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease

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By Hung Nguyen, David Bastian, Byersdorfer C.A, Taylor Ticer
| Cell Reports Verified
Highlights • Lysosomal acid lipase (LAL) is required for donor T cells to induce GVHD • LAL regulates T cell immunity in GVHD target organs • Pharmacological blockade of LAL effectively ameliorates GVHD • Pharmacological blockade of LAL preserves GVL activity Summary Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT).
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