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Articles by C. Erik Hack
Human IAPP is a contributor to painful diabetic peripheral neuropathy
Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet β cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species.
Hamza, le rappeur belge qui explose les compteurs, à la rencontre de ses fans à Bruxelles
Il est l'un des meilleurs rappeurs belges du moment, et il vient de sortir un nouvel album. Pour marquer le coup, le rappeur belge de 28 ans a décidé d'organiser une rencontre avec ses fans ce samedi à Bruxelles. Son nouvel album "Sincèrement" explose les compteurs, réalisant le meilleur démarrage de l'année. Un album dans lequel il se confie davantage. "C'est un truc que j'avais plus de mal à faire auparavant.
Passé colonial : le Palais royal a-t-il exercé des pressions sur la commission parlementaire ?
Chez les libéraux, on balaie tout soupçon. Selon eux, la ligne défendue a toujours été claire : celle du roi Philippe qui, lors de son voyage au Congo avait exprimé ses profonds regrets au peuple congolais. "Depuis le début de la commission, on sent que certains veulent des excuses et une indemnisation. Nous sommes à la fin des travaux de cette commission, les mêmes veulent toujours des excuses et une indemnisation", estime Benoît Piedboeuf, chef de groupe MR à la Chambre.
Evidence for bradykinin release in chronic spontaneous urticaria
Abstract Background Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy weals and/or angioedema and is believed to be driven by mast cell activation. It was shown that excessive mast cell activation during anaphylaxis initiates contact activation, resulting in bradykinin release. Evidence for bradykinin release was never demonstrated in CSU. Objective To study biomarkers of bradykinin release in CSU.
High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
Clinical and Translational Allergy20199:35 https://doi.org/10.1186/s13601-019-0274-7 © The Author(s) 2019 Received: 24 April 2019 Accepted: 20 June 2019 Published: 12 July 2019 Abstract Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency.
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