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Articles by Cao Chen
An expert-level generalist AI for abdominal CT diagnosis
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Contrast-enhanced abdominal computed tomography (CT) is a common imaging modality used as part of the diagnostic evaluation for numerous conditions.
GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma
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Abstract Glypican-3 (GPC3) is highly expressed in hepatocellular carcinoma (HCC), making it an attractive target for chimeric antigen receptor (CAR) T cell therapy; however, this approach has previously shown limited clinical efficacy, potentially owing to high levels of transforming growth factor-β (TGFβ) in the tumour microenvironment1,2,3,4. We therefore engineered CAR T cells with a dominant-negative TGFβ receptor II, which showed enhanced antitumour activity in preclinical studies5.
By Qi Zhang, Qihan Fu, Yinan Shen, Wanyue Cao, Gaowei Jin, Yize Zhang, Jiangchao Wu, Cao Chen, Xingyuan Xu, Ke Sun, Xing Xue, Nick Durham, Mark Cobbold, Yixin Hao, Yi Hong, Jiaqi Huang, Michael Humphries, Gordon Moody, John Stone, Lingyan Sun, Eric Tu, Fei Wang, Yihong Yao, Andy Zou, Xueli Bai, Tingbo Liang, Hongkan Wang, Attilio Bondanza, Daisy Cao, Nina Chu, Benedetto Farsaci, Qijie Jian, Fuzhe Wang
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Nature
Verified
Higher diversity and abundance of microRNA-455-5p isoforms confer suppressive role in Wilms’ tumor
1 Introduction MicroRNAs (miRNAs) are small non-coding RNAs that play crucial regulatory roles in various biological processes, including tumorigenesis (1, 2). During their study of miRNA expression in human embryonic stem cells using deep sequencing in 2008, Morin et al. introduced the term ‘isomiRs’ for miRNAs that differ from their archetype sequence (3).
Data explosion! Outbound travel orders surged 8 times, milk tea shop sales increased 500%, and hot pot leaders received more than 13 million diners
Source: Securities Times e Company Author: Cao Chen During the 8-day "Super Golden week", more than 800 million people traveled abroad and the income from domestic tourism exceeded 750 billion yuan. The "National Day" Golden week is an important window to observe economic vitality, and the constantly refreshed data reflect the surging vitality of China's holiday economy.
Cluster synchronization for controlled nodes via the dynamics of edges in complex dynamical networks
PLOS ONE, Aug 2023 An appropriate dynamic coupling form between nodes and edges’ state can effectively promote the emergence of desired network function (phenomenon), but the existing literatures have not conducted in-depth research on the coupling mechanism. This paper mainly focuses on the coupling auxiliary mechanism of dynamic edges for the emergence of cluster phenomenon of nodes, explores the essential relation between structure and function in complex dynamical networks (CDNs).
An aliphatic MOF with a molecular sieving effect for efficient C2H2/C2H4 separation
An aliphatic MOF with molecular sieving effect for efficient C2H2/C2H4 separation Xian-Zhen Li, Cao Chen, Zi-Wen Fan, Jianfa Liu, Tony Pham, Katherine Forrest and Zheng Niu Abstract A metal-organic framework, SDMOF-1, with the rigid pores of about 3.4 Å, which is appropriate to accommodate the C2H2 molecules, exhibits high C2H2 adsorption capacity and great separation capability of C2H2/C2H4 mixture.
Carboxylic acids and metal ions co-driven assembly of triene coordination polymers for [2+2] photocycloaddition
Carboxylic acids and metal ions co-driven assembly of triene coordination polymers for [2+2] photocycloaddition Xin-Ran Xue, Cao Chen, Yu Ge, Qiu-Yi Li, Min-Jie Zhang, Qi Liu and Jian-Ping Lang Abstract The application of coordination polymers (CPs) as a platform to control the arrangement of olefin-containing ligands to produce cyclobutane derivatives by [2+2] photocycloaddition reactions is a highly regional selective and stereoselective approach.
Accurately predicting postoperative RFS & OS in HCC patients
Introduction Hepatocellular carcinoma (HCC), one of the most common malignancies, is the third leading cause of cancer-related mortality.1 Curative hepatectomy remains the most effective treatment for HCC patients. Unfortunately, the postoperative recurrence rate can reach up to 70% in five years, which causes the dismal survival of HCC patients.2 Due to the high heterogeneity of HCC, it is challenging to develop clinical models to predict precisely the postoperative prognosis of patients.
Shanghai man threw items from high-rise, given year of prison
A man in Shanghai was sentenced to one year in prison by a local court on Friday for intentionally throwing objects out of a 14-story window, endangering public safety. The case is the first involving objects thrown out of a tall building in the city since a related national judicial document was issued by the Supreme People's Court on Nov 14.
Lingang to focus on seven key industries
The Lingang Special Area of the China (Shanghai) Pilot Free Trade Zone released its industrial map presenting the layout of the key industries in the zone on Thursday, the hundredth day since its launch. Seven projects involving a total investment of 15 billion yuan ($2.13 billion) in the special area were also signed.
Chinese production set to create history on Broadway
Shimmer will become the first Chinese musical to have an open-ended run on Broadway. [Photo provided to China Daily] Shanghai Hengyuanxiang (HYX) Drama Development Company and Nederlander Worldwide Entertainment signed a deal on Nov 6 that would see Shimmer become the first Chinese musical to have an openended run on Broadway. Shimmer, which tells a story about Jews who fled to Shanghai to escape Nazi persecution during World War II, premiered at the Shanghai Culture Square in 2015.
A 3D/3D hetero-interpenetrated MOF with a novel (3,9)-c net and 6-c lcy net for the fluorescence detection of carbaryl
A 3D/3D hetero-interpenetrated MOF with a novel (3,9)-c net and 6-c lcy net for the fluorescence detection of carbaryl Rong Shi, Ze-Ming Xu, Cao Chen, Zheng Niu and Jian-Ping Lang Abstract An exceptional Zn-based MOF material with two-fold hetero-interpenetrated nets consisting of a 3D lcy network and a novel 3D (3,9)-coordinated framework has been constructed.
Film about visionary musicians begins production Original
Published: 13:07, September 02, 2022 | Updated: 13:08, September 02, 2022 PDF View Revert PDF View Film about visionary musicians begins production By Cao Chen in Shanghai Bukaopu is a band formed by six musicians with visual challenges who overcome a series of obstacles before impressing audiences. Their story has inspired a film. (PHOTO PROVIDED TO CHINA DAILY) A Miracle Band, which is about six visually impaired musicians, started filming in Shanghai last month.
Prospering naturally
Biologist's dream and vision helps native species return to a habitat where they can thrive, Cao Chen reports. Founder of Forest City Studio Guo Taoran, who leased land in Pujiang Country Park in Shanghai's Minhang district to reintroduce plant and animal species native to, or commonly found in, the city.
Throat swab robots will ease burden on medics
Published: 11:05, July 15, 2022 | Updated: 11:22, July 15, 2022 PDF View Revert PDF View Throat swab robots will ease burden on medics By Cao Chen in Shanghai Testing for COVID-19 normally has kept clinicians clad in medical protective gear working for hours. But sample collecting is stepping closer to full automation with the development of yet another robot. A team at Shanghai University has made a robot that gets a nucleic acid sample with a throat swab in 22 seconds.
Experiential learning
Published: 17:48, June 18, 2022 PDF View Revert PDF View Experiential learning By Cao Chen Graduates master valuable skills and gain real-world wisdom by working at the grassroots level during the fight against the ongoing pandemic, Cao Chen reports in Shanghai. Zhang Shengwei, assistant to the Party secretary in Zhuqiao village in Pudong New Area, Shanghai, carries food rations to the village.
Experiential learning
Published: 17:48, June 18, 2022 PDF View Revert PDF View Experiential learning By Cao Chen Graduates master valuable skills and gain real-world wisdom by working at the grassroots level during the fight against the ongoing pandemic, Cao Chen reports in Shanghai. Zhang Shengwei, assistant to the Party secretary in Zhuqiao village in Pudong New Area, Shanghai, carries food rations to the village.
Teacher looks after lab creatures Original
Huang Linbin, a researcher at the fisheries and life sciences school of Shanghai Ocean University, has lived on campus and attended to lab-managed aquatic creatures during the lockdown. (PHOTO PROVIDED TO CHINA DAILY) While taking care of students who have been locked down on campus since April 10, Huang Linbin, a researcher at the fisheries and life sciences school of Shanghai Ocean University, has also been busy attending to lab-managed aquatic creatures.
First C919 jet to be delivered completes maiden test flight Original
China's indigenously-developed jet, coded B-001J, took off at 6:52 am from Shanghai Pudong International Airport and on May 14, 2022. (XINHUA) The first C919 aircraft to be delivered to China Eastern Airlines completed its debut test flight in Shanghai on Saturday.
Online popularity follows example of reaching out
Published: 17:09, May 08, 2022 | Updated: 20:33, May 08, 2022 PDF View Revert PDF View Online popularity follows example of reaching out By Cao Chen and Wang Yu Meng Yinghong, an undergraduate student of a Hong Kong university, has achieved online popularity for her videos about her experience of staying in Shanghai and helping with COVID-19 containment measures.
Online popularity follows example of reaching out
Published: 17:09, May 08, 2022 PDF View Revert PDF View Online popularity follows example of reaching out By Cao Chen and Wang Yu Meng Yinghong, an undergraduate student of a Hong Kong university, has achieved online popularity for her videos about her experience of staying in Shanghai and helping with COVID-19 containment measures.
A time of service Original
Dedicated volunteer recalls her experience at a makeshift hospital in a phone call with a relative that went viral, Cao Chen reports. (HAN LUYING / FOR CHINA DAILY) Wu Yinping, a 70-year-old Shanghai native, became popular online after a recording of her phone conversation with her niece went viral.
More Shanghai residents permitted outdoors Original
Published: 11:12, May 03, 2022 | Updated: 11:12, May 03, 2022 PDF View Revert PDF View More Shanghai residents permitted outdoors By Cao Chen in Shanghai About 60 percent of city's population live in zones with no cases for 2 weeks A resident in a precautionary zone walks his dog in East China's Shanghai, April 12, 2022.
A new role in business Original
Undergraduate helps create fresh way of teaching entrepreneurial skills and strategies, Cao Chen reports in Shanghai. David Chen (second from left) and his team receive the third prize at the Google Cup Entrepreneurship Competition held at Shanghai Jiao Tong University in 2020. (PHOTO PROVIDED TO CHINA DAILY) Mystery games have enjoyed a growing popularity in China, with throngs of youngsters banding together to spend hours solving fictional crimes.
Weaving history Original
A private art gallery is preserving a traditional, strong and delicate fabric amid changes in lifestyle, Cao Chen reports. Yang Panhong and her husband, Yang Dongye, are determined to preserve the traditional Songjiang cloth through opening an art gallery in Shanghai. The gallery boasts an extensive collection comprising more than 5,000 rolls of Songjiang cloth, and sells creative products made from the fabric, such as dolls, clothes and bags.
Teamwork banishes the office quarantine blues
Colleagues' caring approach and cooperation see them through unusual times Teachers and students line up to take nucleic acid tests on the Songjiang campus of Shanghai University of Engineering Science on March 11. (MA DING / FOR CHINA DAILY) People living and working at locations being used for COVID-19 quarantine in one of China's busiest cities have told of their unforgettable experiences.
Housing subsidies to lure returning talent to Shanghai
By CAO CHEN in Shanghai (China Daily) 10:45, March 08, 2022 Shanghai has revised its favorable housing policies as the city strives to expand its talent pool. In Changning district, apartments and housing subsidies will be available for more students studying abroad and returning to Shanghai for work, according to a policy unveiled recently by the district government.
Shanghai regulations to better protect minors
By CAO CHEN | China Daily | Updated: 2022-02-25 09:26 Primary school students do their homework with the help of volunteers at a day care service center in Caohejing, Xuhui district in Shanghai. [Photo/Xinhua] Shanghai's municipal legislature recently prohibited the provision of cosmetology services to minors without the consent of their parents or guardians and revised other city regulations to better protect minors.
Spreading the words
International students take advantage of scholarship program that aims to nurture Chinese-language teachers, Cao Chen reports in Shanghai. International students learn about tea culture during a Chinese-language teachers scholarship program at East China Normal University.
Spreading the words
International students take advantage of scholarship program that aims to nurture Chinese-language teachers, Cao Chen reports in Shanghai. International students learn about tea culture during a Chinese-language teachers scholarship program at East China Normal University.
Depicting the character of the Games
By Cao Chen | China Daily | Updated: 2022-01-22 09:05 Shanghai-based artist Wang Xuyuan finds inspiration in a cacophony of sound from uplifting music and videos about winter sports competitions.
University unveils microbial gene catalog
By CAO CHEN | China Daily | Updated: 2021-12-20 09:16 [Photo/IC] A team from Fudan University in Shanghai has launched the world's most comprehensive global microbial gene catalog - a database containing 303 million unigenes that will help researchers better understand the relationship between microorganisms and human health. A unigene is a representative DNA sequence of gene sequences that stem from the same microbial species.
Restoring heritage
Giving historical buildings a new look while retaining their original essence has become a major project for a company, Cao Chen reports in Shanghai. The iconic Wukang Mansion at the junction of Wukang Road and Huaihai Middle Road is one of the most celebrated historical buildings in the former French concession area in Shanghai.
Fudan University bestows awards on top management talent
Xu Qingrui, professor of the School of Management at Zhejiang University. (PHOTO PROVIDED TO CHINA DAILY) Five Chinese scholars and entrepreneurs who have made contributions to management science received awards from the Fudan University Management Award Foundation on Friday. The foundation was launched in 2005 to honor those who have made outstanding achievements in the field of management in China.
Students do their part for global governance
The team led by Takudzwa Duncan Maluwa (far right) from Zimbabwe, an undergraduate student in international relations from Beijing International Studies University, won the "most valuable project" award. (PHOTO PROVIDED TO CHINA DAILY) The Rong Chang Cup Youth Innovation Competition on Global Governance in Huzhou, Zhejiang province, came to a close on July 31.
Smart approach taken to boost sporting prowess
Su Bingtian (right) and Wu Zhiqiang compete for China in the men's 4x100 meters semifinal relay at the Tokyo 2020 Olympics on Aug 5. (WANG LILI / XINHUA) Smarter technology and techniques are being harnessed by China to enable athletes representing the nation to improve their training and boost their strength. Many sports colleges and research institutes in China provided scientific and technological support for the Tokyo 2020 Olympics.
Finding balance in a numbers game
Xiong Bin, director of the International Mathematical Olympiad Research Center at East China Normal University. (PHOTO PROVIDED TO CHINA DAILY) Competition training is supplemental to in-class math education for primary and secondary school students in China, but further research and practice is still necessary to identify the role of competitions in popularizing the study among the public and selecting top talent, a math scholar says.
New venue showcases Party's foundation
Shanghai memorial site welcomes 10,000 visitors a day Visitors to the new memorial site photograph the oil painting Spark, which features the 50-plus founding members of the Communist Party of China. (LIU YING / XINHUA) The Communist Manifesto, by the two great German thinkers Karl Marx and Friedrich Engels, was first published in China in August 1920.
Preserving poetry's charm
Translation master hopes his interpretations of ancient works will help more people understand traditional Chinese culture, Cao Chen reports in Shanghai. Zhao Yanchun, a professor of translation at Shanghai University, has published collections of English translations of poems by four renowned Tang Dynasty (618-907) poets, Li Bai, Du Fu, Wang Wei and Bai Juyi.
Creations exhibit harmony with tradition
Friday, May 28, 2021, 11:44 PDF View Revert PDF View Creations exhibit harmony with tradition By Cao Chen Friday, May 28, 2021, 11:44 By Cao Chen Fridge magnets and a Miao ethnic embroidery piece are among the creative products on show at a floral design exhibition at the flower expo. (PHOTO PROVIDED TO CHINA DAILY) On Shanghai's Chongming Island, a floral design exhibition will run from June 5 to 20 at the 10th China Flower Expo.
Creations exhibit harmony with tradition
Friday, May 28, 2021, 11:44 PDF View Revert PDF View Creations exhibit harmony with tradition By Cao Chen Friday, May 28, 2021, 11:44 By Cao Chen Fridge magnets and a Miao ethnic embroidery piece are among the creative products on show at a floral design exhibition at the flower expo. (PHOTO PROVIDED TO CHINA DAILY) On Shanghai's Chongming Island, a floral design exhibition will run from June 5 to 20 at the 10th China Flower Expo.
Creations exhibit harmony with tradition
By Cao Chen | China Daily | Updated: 2021-05-28 09:29 Fridge magnets and a Miao ethnic embroidery piece are among the creative products on show at a floral design exhibition at the flower expo.[Photo provided to China Daily] On Shanghai's Chongming Island, a floral design exhibition will run from June 5 to 20 at the 10th China Flower Expo. The exhibition will showcase creative products, poems and literature related to flowers and other types of plants.
Flower expo in full blossom
Event drives development of area, spurring maturity of its environmentally friendly industries, Xing Yi and Cao Chen report in Shanghai. The Century Pavilion of the 10th China Flower Expo is shaped like a giant butterfly. (PHOTO PROVIDED TO CHINA DAILY) After more than 1,000 days of preparation, the 10th China Flower Expo opened in Shanghai's Chongming Island on May 21.
Sublime treats to delight the senses
Century Pavilion, the major venue of 10th China Flower Expo, is shaped like a butterfly. (PHOTO PROVIDED TO CHINA DAILY) The 10th China Flower Expo will open in Shanghai’s Chongming Island on May 21 and run through July 2. The expo, considered the premiere gardening-themed event in China, will span 10 square kilometers and feature a peony-shaped flower field, six pavilions showcasing flowers from around the world and six gardens for floral art.
A moving account
Australian TV host touched by stories of China's poverty alleviation during the making of new documentary, Alywin Chew and Cao Chen report in Shanghai. A scene from China on the Move shows Guo Yi, a ranger of Ant Forest Project, in a desert in Gansu province.
Shanghai breakfast van serves meals for quarantined residents
By CAO CHEN | China Daily | Updated: 2021-01-29 08:10 A volunteer buys breakfast from a van at Guixi residential community in Shanghai on Tuesday. The community was listed as a medium-risk area for novel coronavirus and went into closed management on Sunday. [Photo/Xinhua] A Shanghai breakfast van has branched out this week, offering meals to residents in a neighborhood quarantined due to COVID-19.
Meeting history
The team responsible for running the site of the Party's First National Congress explains how they're innovating to better engage the public, Cao Chen reports in Shanghai. The Site of the First National Congress of the Communist Party of China in Shanghai hosts a wide range of activities to help visitors learn about the history of the CPC.
Renovations of historic CPC site to be completed in May
By Cao Chen in Shanghai | chinadaily.com.cn Updated: Jan 11, 2021 The renovation of the Memorial for the Site of the First National Congress of the Communist Party of China in Shanghai will be completed by May, in time for the upcoming centenary of the founding of the Party in July, according to a staff member from the memorial.
More than just mindless fun
By Cao Chen | China Daily | Updated: 2020-12-25 08:05 The ongoing exhibition, Player of Beings, in Shanghai features an interactive computer-graphics installation by Jeffrey Shaw, Fall Again, Fall Better, which explores another aspect of games－their relationship with life and death. [Photo provided to China Daily] A new exhibition at the Ming Contemporary Art Museum in Shanghai explores the intrinsic relationship between video games and life.
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