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Yinan Shen

As seen in: Nature, Wiley Online Library, Gut Journal, Science Magazine, Royal Society of Chemistry, Cell Press
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Articles

GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

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By Qi Zhang, Qihan Fu, Yinan Shen, Wanyue Cao, Gaowei Jin, Yize Zhang, Jiangchao Wu, Cao Chen, Xingyuan Xu, Ke Sun, Xing Xue, Nick Durham, Mark Cobbold, Yixin Hao, Yi Hong, Jiaqi Huang, Michael Humphries, Gordon Moody, John Stone, Lingyan Sun, Eric Tu, Fei Wang, Yihong Yao, Andy Zou, Xueli Bai, Tingbo Liang, Hongkan Wang, Attilio Bondanza, Daisy Cao, Nina Chu, Benedetto Farsaci, Qijie Jian, Fuzhe Wang
| Nature Verified
Abstract Glypican-3 (GPC3) is highly expressed in hepatocellular carcinoma (HCC), making it an attractive target for chimeric antigen receptor (CAR) T cell therapy; however, this approach has previously shown limited clinical efficacy, potentially owing to high levels of transforming growth factor-β (TGFβ) in the tumour microenvironment1,2,3,4. We therefore engineered CAR T cells with a dominant-negative TGFβ receptor II, which showed enhanced antitumour activity in preclinical studies5.
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Integrated Multi-Omics Analysis of Coagulation Dysregulation and Immune Pathway Alterations in 10-Gene Pig-to-Monkey Liver Xenotransplantation: A Case Report

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By Wei Zhang, Rongrong Wang, Xuan Zhang, Zhiwei Li, Yinan Shen, Min Xu, Xin Duan, Ying Chen, Jie Xiang, Xiaoyuan Zhang, Jinyan Huang, Shunliang Gao, Kaixiang Xu, Xueli Bai, Hongjiang Wei, Tingbo Liang, Yingjiqiong Liang, Huanglei Tang
| Wiley Online Library Verified
1 Introduction End-stage liver disease represents a major global health burden, accounting for approximately two million deaths each year worldwide [1, 2]. Liver transplantation remains the definitive therapeutic option for patients with end-stage liver disease [3]; however, its widespread application is severely constrained by the persistent shortage of suitable human donor organs [4].
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International conferences must include China

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By Yifang Ma, Yinan Shen, Hai Rao
| Science Magazine Verified
Opens in a new window Opens an external website Opens an external website in a new window This website utilizes technologies such as cookies to enable essential site functionality, as well as for analytics, personalization, and targeted advertising. To learn more, view the following link: Privacy Policy Skip to main content Main content starts here Yifang Ma, Yinan Shen, and Hai RaoAuthors Info & Affiliations Access the full article View all access options to continue reading this article.
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