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Carl Pepine

As seen in: Nature, Wiley, Wiley Online Library, MDPI, Medscape, Science Magazine, AHA/ASA Journals, Healio, Healio Cardiac/Vascular Intervention, Healio Cardiology and
Be kind, do your best and treat others the way you'd want to be treated. "Never let the fear of striking out keep you from playing the game." Babe Ruth
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Articles

A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials

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By Qianqian Yang, Zeinab Bidel, Dexter Canoy, Guyu Zeng, William C. Cushman, Anthony Rodgers, Koon K. Teo, Barry Davis, John Chalmers, Carl Pepine, Johan Sundström, Mark Woodward, Milad Nazarzadeh, Kazem Rahimi
| Nature Verified
Abstract Blood pressure (BP)-lowering therapy reduces cardiovascular risk, but whether its proportional benefits increase with longer treatment duration remains unclear. We conducted an individual participant-level data meta-analysis of 51 randomized trials from the Blood Pressure Lowering Treatment Trialistsʼ Collaboration (358,642 participants; median follow-up: 4.2 years).
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Artificial intelligence-enabled plaque characterization from coronary computed tomography establishes basis of angina in women with nonobstructive atherosclerosis

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By Rafal Wolny, Kajetan Grodecki, Caroline Park, Rebekah Park, Jacek Kwiecinski, Osama Dasa, Vinicius Calsavara, Daniel Berman, Piotr Slomka, Matthew J. Budoff, Eileen M. Handberg, Carl Pepine, Leslee J. Shaw, Janet Wei, Martha Gulati, C. Noel Bairey Merz, Balaji Tamarappoo, Damini Dey, Guadalupe Flores Tomasino, Joel Lenell
| Nature Verified
Abstract Half of women with ischemic symptoms have non-obstructive coronary artery disease (CAD), while the pathophysiology of their condition has not been characterized. Noncalcified (NCP) and low-attenuation plaque (CT density<30 Hounsfield units, LAP) burden quantified from coronary computed tomography angiography (CCTA) is associated with ischemia in patients with obstructive CAD.
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Effectiveness and Efficiency of an Add-on Active Outreach Strategy on Research Enrollments in a Drug Intervention Trial

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By Grant Scheiffele, Teresa Lyles, Carl Pepine, Alfred K. Cheung
| Journal of Clinical Epidemiology Verified
ClinicalTrial.Gov Registration: NCT03636152 •Actively reaching out to people who were mail-invited for research studies but did not respond may allow more people the opportunity for research participation and increase clinical research recruitments; however, the effectiveness of such an approach has not been formally tested for research studies outside the population and behavioral health.
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