Caroline Bartman
As seen in:
The New York Times,
Nature,
Yahoo,
BioRxiv,
Cell Metabolism,
Cell Press,
RealClear Politics,
The Journal of Immunology
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Brown adipose tissue ankyrin-B cell-autonomously modulates lipid content and its deletion protects male mice against diet-induced obesity
Abstract Fatty acid (FA) availability for brown adipose tissue (BAT) thermogenesis depends in part on lipolysis of lipid droplet (LD) triglycerides. Here, we identify the membrane adaptor ankyrin-B (AnkB), encoded by the cardiometabolic disease-associated ANK2 gene, as a regulator of brown adipocyte lipid homeostasis and metabolic adaptation.
Metabolic and transcriptional plasticity supports CD8 + T cell resilience and anti-tumor immunity under nutrient stress
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Keywords T cells CD8+ T cells T cell exhaustion anti-tumor immunity stress adaptation translation polysome profiling nutrient stress mTOR integrated stress response GCN2 HRI ATF4 CEBPG tumor-infiltrating lymphocyte immunometabolism amino acids Get full text access Log in, subscribe or purchase for full access. References 1. Palm, W. ∙ Thompson, C.B. Nutrient acquisition strategies of mammalian cells Nature. 2017; 546:234-242 2. Zhu, J.
By Michael Scaglione, Montana S. Knight, Krittin Trihemasava, Anne-Sophie Archambault, Juhee Oh, Erin Tanaka, Elise Hall, Tran Ngoc Van Le, Caleb Lines, Brian P Goldspiel, Hossein Fazelinia, Clemence Queriault, Lucien H. Turner, Tanay Parnaik, Jimmy Xu, Morgan Brown, Oishi Bardhan, Jessie E. Axsom, Frederick C. Bennett, Lynn Spruce, Caroline Bartman, Clementina Mesaros, Ramon I. Klein Geltink, Crystal S. Conn, Will Bailis
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Cell Press
Verified
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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Keywords lactate metabolism metabolic homeostasis insulin signaling HCAR1 signaling competitive catabolism TCA cycle insulin resistance diabetes mellitus metabolic flux quantitative modeling Get full text access Log in, subscribe or purchase for full access. References 1. Brooks, G.A. The Science and Translation of Lactate Shuttle Theoryy Cell Metab. 2018; 27:757-785 2. Gladden, L.B. Lactate metabolism: a new paradigm for the third millennium J. Physiol. 2004; 558:5-30 3. Zhang, D. ∙ Tang, Z. ∙ Huang, H.
By Won Dong Lee, Daniel R. Weilandt, Lingfan Liang, Michael R. MacArthur, Natasha Jaiswal, Olivia Ong, Charlotte Mann, Qingwei Chu, Craig Hunter, Rolf-Peter Ryseck, Wenyun Lu, Anna M. Oschmann, Alexis J. Cowan, Tara TeSlaa, Caroline Bartman, Cholsoon Jang, Joseph A. Baur, Paul M. Titchenell, Joshua D. Rabinowitz
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Cell Metabolism
Verified
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