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Oishi Bardhan

As seen in: BioRxiv, Cell Press
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Articles

Metabolic and transcriptional plasticity supports CD8 + T cell resilience and anti-tumor immunity under nutrient stress

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By Michael Scaglione, Montana S. Knight, Krittin Trihemasava, Anne-Sophie Archambault, Juhee Oh, Erin Tanaka, Elise Hall, Tran Ngoc Van Le, Caleb Lines, Brian P Goldspiel, Hossein Fazelinia, Clemence Queriault, Lucien H. Turner, Tanay Parnaik, Jimmy Xu, Morgan Brown, Oishi Bardhan, Jessie E. Axsom, Frederick C. Bennett, Lynn Spruce, Caroline Bartman, Clementina Mesaros, Ramon I. Klein Geltink, Crystal S. Conn, Will Bailis
| Cell Press Verified
Keywords T cells CD8+ T cells T cell exhaustion anti-tumor immunity stress adaptation translation polysome profiling nutrient stress mTOR integrated stress response GCN2 HRI ATF4 CEBPG tumor-infiltrating lymphocyte immunometabolism amino acids Get full text access Log in, subscribe or purchase for full access. References 1. Palm, W. ∙ Thompson, C.B. Nutrient acquisition strategies of mammalian cells Nature. 2017; 546:234-242 2. Zhu, J.
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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state and its deletion improves checkpoint blockade

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By Susan McClory, Josephine Giles, Amy Baxter, Oishi Bardhan
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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