Do supermarket treatments for depression work? An expert weighs in Supplements are more popular than prescription medicines among Australians with depression (Getty/iStock) Australians have long been some of the highest users of herbal and nutritional supplements that claim to boost mood or ease depression. These include omega-3s (found in fish oil), St John’s wort, probiotics and vitamin D. In fact, among Australians with depression, these supplements are more popular than prescription medicines.