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Articles by Chaim Glück
Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Visualization of cellular dynamics in microvascular networks is essential for deciphering physiology and disease.
Intrinsic endothelial remodeling drives brain capillary repair
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Keywords cerebral microvasculature brain endothelium endothelial cell death endothelial remodeling capillary repair microvascular dynamics in vivo two-photon imaging stroke microstroke Introduction The brain is critically dependent on the proper functioning of its intricate vasculature, which ensures a continuous supply of oxygen and nutrients while removing metabolic wastes.1,2,3,4 An elaborate capillary network is formed during development and maintained throughout life to support these...
By Jacqueline Condrau, Chaim Glück, Matthias T. Wyss, Ladina Hösli, Eva Erlebach, Henri S. Zanker, Alexandra von Faber-Castell, Luca Ravotto, Gina Eberle, Srinivasa R. Allu, Tatiana V. Esipova, Thomas Troxler, Jeffrey Bennett, Marina Herwerth, Susanne Wegener, Aiman S. Saab, Sergei A. Vinogradov, Mohamad El Amki, Bruno Weber
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Cell Press
Verified
Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull
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Abstract Quantitative, volumetric imaging of cerebrovascular networks and microcirculation is essential for understanding brain function. However, rapid mesoscopic 3D imaging remains challenging because of fundamental trade-offs between spatiotemporal resolution, field of view, and sensitivity to functional parameters. Here we present a mesoscopic fluorescence imaging platform featuring a double-helix phase mask for real-time, depth-resolved measurements through the intact mouse skull.
By Baoyuan Zhang, Shiyao Guo, Lin Tang, Yi Chen, Lukas Glandorf, Xuyang Chang, Tian Jin, Michael Reiss Verified, Shuxin Lyu, Qiang Fu, Wolfgang Heidrich, Chaim Glück, Dominik Schillinger, Bruno Weber, Xosé Luís Déan-Ben, Weibo Wang, Xiong Dun, Daniel Razansky, Zhenyue Chen, Quanyu Zhou, Etienne Jessen, Hadi Amata
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Nature
Verified
Coordinated Two‐Photon Fluorescence and Optoacoustic Microscopy of Neural, Vascular, and Cellular Dynamics in the Mouse Brain
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description lpor70021-sup-0001-SuppMat.pdf868.3 KB Supporting Information lpor70021-sup-0002-MovieS1.mp418 MB Supplemental Movie 1 References 1, , , Nat. Neurosci. 2018, 21, 174. 2, , Nat. Rev. Phys. 2019, 1, 318. 3, , , Life 2023, 13, 1472. 4, , , , , , , , Inform. Fusion 2020, 64, 149. 5, , , , , , , , , , , Nat. Biomed. Eng. 2022, 6, 584. 6, , , , , , , , , , Nat. Rev. Method Prime. 2021, 1, 18.
A chemogenetic approach for dopamine imaging with tunable sensitivity - Nature Communications
Abstract Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. Here we show that a human-selective dopamine receptor positive allosteric modulator (PAM) can be used to boost sensor affinity on-demand.
Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells - Nature Communications
Abstract Large-scale imaging of brain activity with high spatio-temporal resolution is crucial for advancing our understanding of brain function. The existing neuroimaging techniques are largely limited by restricted field of view, slow imaging speed, or otherwise do not have the adequate spatial resolution to capture brain activities on a capillary and cellular level.
Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization
Highlights • LMCs maintain perfusion during stroke • Upon recanalization, LMCs allow for a gradual reperfusion • In mice with poor LMCs, recanalization causes deleterious hyperperfusion • Stroke patients with poor LMCs show fast reperfusion and futile recanalization Summary Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot removal, many stroke patients recover poorly.
The role of leptomeningeal collaterals in redistributing blood flow during stroke
Citation: Epp R, Glück C, Binder NF, El Amki M, Weber B, Wegener S, et al. (2023) The role of leptomeningeal collaterals in redistributing blood flow during stroke. PLoS Comput Biol 19(10): e1011496. https://doi.org/10.1371/journal.pcbi.1011496 Editor: Timothy W. Secomb, University of Arizona, UNITED STATES Received: December 30, 2022; Accepted: September 3, 2023; Published: October 23, 2023 Copyright: © 2023 Epp et al.
Ultrasound trapping and navigation of microrobots in the mouse brain vasculature - Nature Communications
Abstract The intricate and delicate anatomy of the brain poses significant challenges for the treatment of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in hard-to-reach brain regions remains an urgent medical need. Microrobots offer potential solutions; however, their functionality in the brain remains restricted by limited imaging capabilities and complications within blood vessels, such as high blood flows, osmotic pressures, and cellular responses.
Deep optoacoustic localization microangiography of ischemic stroke in mice - Nature Communications
Abstract Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible dichloromethane-based microdroplets exhibiting several orders of magnitude higher optical absorption than red blood cells at near-infrared wavelengths, thus enabling single-particle detection in vivo.
Acoustic trapping and navigation of microrobots in the mouse brain vasculature
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Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke
Highlights • Reperfusion failure despite clot retrieval leads to unfavorable outcome in stroke • In the thrombin model of stroke, ≈30% capillaries remain occluded after thrombolysis • Capillaries are plugged by neutrophils, hindering blood flow • Neutrophil depletion facilitates capillary reperfusion and stroke recovery Summary Despite successful clot retrieval in large vessel occlusion stroke, ∼50% of patients have an unfavorable clinical outcome.
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