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Chamandi S. Dampalla on Muck Rack

Chamandi S. Dampalla

As seen in: PNAS, ACS Publications
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Articles

Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies

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By Chamandi S. Dampalla, Yunjeong Kim, Dennis Howard, Alexandria Zabiegala
| ACS Publications
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Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies

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By Chamandi S. Dampalla, Yunjeong Kim, Alexandria Zabiegala, Dennis Howard
| dx.doi.org
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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

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By Jian Zheng, Lok-Yin Roy Wong, Chamandi S. Dampalla, Krishani Dinali Perera
| PNAS Verified
Significance Protease inhibitors targeting viral 3C-like protease are attractive therapeutic options for COVID-19. Here, we synthesized deuterated variants of a coronavirus protease inhibitor, GC376, and determined the therapeutic efficacy in a lethal mouse model. The transgenic mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19, develop lung pathology resembling that of severe COVID-19 patients and were used for antiviral drug testing.
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