Krishani Dinali Perera on Muck Rack

Krishani Dinali Perera

As seen in: PNAS
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Articles

Human Endogenous Retroviruses and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Emerging Insights into Their Role in Disease Pathogenesis, Immune Dysregulation, and as Potential Biomarkers and Therapeutic Targets

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By Krishani Dinali Perera, Elisa Garcia Verified, Simon R. Carding
| preprints.org
This open access article is published under a , which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Open in Who Shared View Duplicates (356) Issue with article?

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

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By Jian Zheng, Lok-Yin Roy Wong, Chamandi S. Dampalla, Krishani Dinali Perera
| PNAS Verified
Significance Protease inhibitors targeting viral 3C-like protease are attractive therapeutic options for COVID-19. Here, we synthesized deuterated variants of a coronavirus protease inhibitor, GC376, and determined the therapeutic efficacy in a lethal mouse model. The transgenic mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19, develop lung pathology resembling that of severe COVID-19 patients and were used for antiviral drug testing.
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