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Articles by Changbin Chen
Mechanism and plasticity of primitive pyroptosis
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores.
Candida albicans synergizes with Fusobacterium nucleatum in colorectal cancer progression via the Flo9-RadD interaction
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Keywords Fusobacterium nucleatum Candida albicans colorectal cancer microbiota fungi Flo9 RadD Get full text access Log in, subscribe or purchase for full access. References 1. Helmink, B.A. ∙ Khan, M.A.W. ∙ Hermann, A. ... The microbiome, cancer, and cancer therapy Nat. Med. 2019; 25:377-388 2. Sepich-Poore, G.D. ∙ Zitvogel, L. ∙ Straussman, R. ... The microbiome and human cancer Science. 2021; 371, eabc4552 3. Garrett, W.S. The gut microbiota and colon cancer Science. 2019; 364:1133-1135 4. Hanahan, D.
By Jialu Li, Chenyi Zhang, Xinhua Huang, Hongxiang Sun, Hongzhi Liu, Lu Zhang, Ningbo Wu, Yuanhong Xie, Jingjing Qi, Xiaoxu Leng, Yun Cui, Ziran Kang, Zhuolei Kou, Ning-Ning Liu, Pengfei Lan, Beilei Xuan, Dengfeng Cao, Guo-Xiang Cai, Yingxuan Chen, Jianfeng Chen, Zhaoyuan Liu, Florent Ginhoux, Changbin Chen, Bing Su, Jing-Yuan Fang
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Cell Press
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Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection - Nature Communications
Abstract Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection.
Global fungal-host interactome mapping identifies host targets of candidalysin - Nature Communications
Abstract Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we performed a high-throughput enhanced yeast two-hybrid (HT-eY2H) screen to map the interactome of all eight Ece1 peptides with their direct human protein targets and identified a list of potential interacting proteins, some of which were shared between the peptides.
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