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Chaoxia Zhu on Muck Rack

Chaoxia Zhu

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Independent associations of clonal hematopoiesis of indeterminate potential and mosaic Y loss with all-cause and cause-specific mortality in men

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By Ying Sun, Yuefeng Yu, Lingli Cai, Xiao Wei Tan, Yingli Lu, Ningjian Wang, Yuying Wang, Fangzhen Xia, Chaoxia Zhu
| Nature Verified
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic loss of the Y chromosome (mLOY) are age-related somatic genomic mutations linked to mortality, yet their independent and combined associations with mortality remain incompletely characterized. We analyzed 205,543 UK Biobank men with CHIP and mLOY status derived from genomic data and followed them for all-cause and cause-specific mortality. During a median follow-up of 15.3 years, 28,164 deaths occurred.
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