Yingli Lu

Abstract Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic loss of the Y chromosome (mLOY) are age-related somatic genomic mutations linked to mortality, yet their independent and combined associations with mortality remain incompletely characterized. We analyzed 205,543 UK Biobank men with CHIP and mLOY status derived from genomic data and followed them for all-cause and cause-specific mortality. During a median follow-up of 15.3 years, 28,164 deaths occurred.

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Atrial fibrillation (AF) is the most common type of sustained arrhythmia, accounting for significant morbidity and mortality.1 According to the 2021 Global Burden of Disease (GBD) study, AF/atrial flutter affected 52.55 million individuals worldwide, a 137% increase from 1990, and associated deaths have doubled since 1990.2 In contrast to the previous definition based on the arrhythmia duration, the new categorization proposed by the most recent guideline describes AF as a progressive disease...