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Articles by Chenlu Yang
A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma
Keywords pancreatic cancer PDAC malignancy PanIN re-epithelialization stereo-seq spatial transcriptomics FOSL1 CTHRC1-expressing myCAF Get full text access Log in, subscribe or purchase for full access. References 1. Mizrahi, J.D. ∙ Surana, R. ∙ Valle, J.W. ... Pancreatic cancer Lancet. 2020; 395:2008-2020 2. Ryan, D.P. ∙ Hong, T.S. ∙ Bardeesy, N. Pancreatic adenocarcinoma N. Engl. J. Med. 2014; 371:1039-1049 3. Orth, M. ∙ Metzger, P. ∙ Gerum, S. ...
Optimizing treatment for Waldenström macroglobulinemia-associated acquired von Willebrand syndrome: a case report and literature review
Abstract Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that is often caused by lymphoproliferative neoplasms such as Waldenström macroglobulinemia (WM). Treatment of AVWS comprises both the control of bleeding and the management of underlying diseases. As the frontline treatment of WM has rapidly evolved, the optimal regimen for AVWS secondary to WM (AVWS-WM) has yet to be elucidated.
Frontiers | Born with two faces: sequential DLBCL, NOS and TFHL-AI with TET2 mutation – a case report
Introduction Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) is a lymphoid malignancy in adults characterized by significant clinical and genetic heterogeneity (1). Nodal T follicular helper cell lymphoma, angioimmunoblastic type (TFHL-AI), a subtype of mature T-cell lymphoma, is associated with poor prognosis. Key mutations frequently observed in TFHL-AI include RHOA, TET2, DNMT3A, and IDH2 (2).
ASAH1-mediated sphingolipid metabolic reprogramming in venetoclax resistance of AML: beyond the monocytic phenotypes - BMC Cancer
References Lagadinou ED, Sach A, Callahan K, et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell. 2013;12:329–41. https://doi.org/10.1016/j.stem.2012.12.013. Google Scholar Pan R, Hogdal LJ, Benito JM, et al. Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia. Cancer Discov. 2014;4:362–75. https://doi.org/10.1158/2159-8290.CD-13-0609.
Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury
Keywords lung ischemia-reperfusion injury neutrophil CD177 oxidative phosphorylation mitochondrial complex I Introduction Primary graft dysfunction (PGD), a clinical manifestation of ischemia-reperfusion injury (IRI) following lung transplantation, affects approximately 15%–25% of recipients within the initial 72 h post-transplantation.1,2,3 It is the principal cause of short-term mortality, premature graft failure, and chronic rejection.
Transcriptional conservation and evolutionary divergence of cell types across mammalian hypothalamus development
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1State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China 2University of Chinese Academy of Sciences, Beijing 100101, China 3BGI Research, Beijing 102601, China 4Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 511436, China 5Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China 6Department of...
By Zhen-Hua Chen, Taotao Pan, Yu-Hong Zhang, Ben Wang, Xue-Lian Sun, Meixi Gao, Yang Sun, Mingrui Xu, Shuhui Han, Xiang Shi, Felipe Corrêa-da-Silva, Chenlu Yang, Junfu Guo, Haoda Wu, Yu Li, Xiu-Qin Liu, Fei Gao, Zhiheng Xu, Shengjin Xu, Xin A. Liu, Ying Zhu, Ziqing Deng, Shiping Liu, Yi Zhou, Chun-Xia Yi, Longqi Liu, Qing-Feng Wu
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Cell Press
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The Impact of Farmland Transfer on Urban-Rural Integration: Causal Inference Based on Double Machine Learning
1. Introduction and Literature Review 1.1. Introduction Urban–rural ties constitute essential economic and social dynamics, with several countries worldwide examining the framework of these relations during urbanisation, in alignment with their national contexts [1]. The enduring urban–rural dual structure in China has intensified the issue of uneven urban–rural growth, significantly hindering the modernisation of agriculture and rural regions as well as balanced urban–rural progress.
Association Between Renal Function and Mortality Among Patients With Acute Pulmonary Embolism in Plateau Regions: A Retrospective Cohort Study
Ayuda Buscar en la ayuda Buscar en la ayuda Association Between Renal Function and Mortality Among Patients With Acute Pulmonary Embolism in Plateau Regions: A Retrospective Cohort Study Chenlu Yang [1] ; Yanmin Liu [2] ; Ning Wang [2] ; Jie Huang [2] ; Yajun Tuo [3] ; Xiaokai Feng [3] [1] Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China [2] Department of...
Extracts of Dunkelfelder Grape Seeds and Peel Increase the Metabolic Rate and Reduce Fat Deposition in Mice Maintained on a High-Fat Diet
Open AccessArticle by 1, 1, 1, 1, 1,2,3 and 1,2,3,* 1 College of Enology, Northwest A&F University, Yangling 712100, China 2 China Wine Industry Technology Institute, Yinchuan 750021, China 3 Shaanxi Engineering Research Center for Viti-Viniculture, Yangling 712100, China * Author to whom correspondence should be addressed.
Ultrafine Rh nanoparticles decorated MoSe2 nanoflowers for efficient alkaline hydrogen evolution reaction
The development of highly efficient and stable electrocatalysts for the hydrogen evolution reaction (HER) under alkaline media is of great importance due to its sluggish water dissociation kinetics. In this work, ultrafine Rh nanoparticles decorated MoSe2 nanoflowers have been synthesized through a colloidally synthetic method.
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