Chetanchandra S. Joshi

Keywords Female, Mice, Animals, Urinary Tract Infections, Urinary Tract, Urinary Bladder, Aging, Homeostasis, Immunity, Innate, Aging, Urinary Tract Infection, tertiary lymphoid tissue, Autophagy, ROS, CXCL13, TNFα, Estrogen, D-mannose Abstract A global increase in older individuals creates an increasing demand to understand numerous healthcare challenges related to aging. This population is subject to changes in tissue physiology and the immune response network.

Keywords Mice, Female, Animals, NLR Family, Pyrin Domain-Containing 3 Protein, Urinary Bladder, Mannose, Reactive Oxygen Species, Escherichia coli, Urothelium, Interleukin-1beta, Gasdermins, Urinary Tract Infections, Cellular Senescence Abstract Aging is a risk factor for disease via increased susceptibility to infection, decreased ability to maintain homeostasis, inefficiency in combating stress, and decreased regenerative capacity.

Main text Urinary tract infections (UTIs) are common and frequently recurrent. The majority of UTIs are caused by uropathogenic Escherichia coli (UPEC). Detailed molecular events that underlie UPEC colonization and persistence in the bladder have been characterized in several elegant studies over the past 20 years in mouse models, human cell lines, and organoids. ) through packaging into fusiform vesicles (FVs) of the GTPase RAB27B.