Chia-Ying Huang

Abstract X-ray crystallographic fragment screening is a powerful strategy in modern drug discovery, enabling the identification of small-molecule starting points for rational hit-to-lead optimization.

Significance Solid-state NMR (ssNMR) is an atomic-level method for determining the structure and dynamics of membrane proteins that complements more static structural information provided by crystallography, single particle cryoelectron microscopy, and prediction methods. Since preparation of protein-laden membranes for ssNMR can be challenging, more convenient membrane mimetic systems are needed.

Abstract Time-resolved serial crystallography at X-ray Free Electron Lasers offers the opportunity to observe ultrafast photochemical reactions at the atomic level. The technique has yielded exciting molecular insights into various biological processes including light sensing and photochemical energy conversion.