Gebhard Schertler

Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Human daytime vision relies on a trio of visual receptors called opsins, which are found in the cone cells in and around the central region of the retina.

Significance Determining the 3D structures of proteins is essential for understanding how they function. However, proteins structural biology is challenging, and the currently available methods used for structural studies have many limitations. Recent advances in a relatively new method, microcrystal electron diffraction (MicroED), have the potential to broaden the range of accessible targets for structural study.

Abstract Time-resolved serial crystallography at X-ray Free Electron Lasers offers the opportunity to observe ultrafast photochemical reactions at the atomic level. The technique has yielded exciting molecular insights into various biological processes including light sensing and photochemical energy conversion.