Ching-Chuan Kuo

Results Here, we analyzed three clinical datasets (GEO: GSE25066 n = 508, GEO: GSE41998 n = 297, and GEO: GSE32646 n = 115) to identify differentially expressed genes in TNBC. The detailed analysis workflow is outlined in the supplemental information and depicted in Figure S1A. KIF2C emerged as the only target meeting the following criteria: (1) overexpression in all subtypes of TNBC vs.

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Microtubule-targeting drugs, such as taxotere, epothilone B, discodermolide, vincristine, 2-methoxyestradiol, and colchicine, can downregulate the expression of HIF-1α protein but not HIF-1α mRNA [25]. MPT0B098, a novel indoline-sulfonamide-based microtubule inhibitor, can destabilize HIF-1α mRNA in hypoxia by inhibiting the translocation of HuR from the nucleus to cytoplasm [12]. This ability distinguishes MPT0B098 from other microtubule inhibitors.