Chorong Park

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 7 June 2024 / Approved: 7 June 2024 / Online: 7 June 2024 (08:08:13 CEST) Megawati, D.; Stroup, J. N.; Park, C.; Clarkson, T.; Tazi, L.; Brennan, G.; Rothenburg, S. Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion. Preprints 2024, 2024060459. https://doi.org/10.20944/preprints202406.0459.v1 Megawati, D.; Stroup, J.

Abstract The antiviral protein kinase R (PKR) is activated by viral double-stranded RNA and phosphorylates translation initiation factor eIF2alpha, thereby inhibiting translation and virus replication. Most poxviruses contain two PKR inhibitors, called E3 and K3 in vaccinia virus (VACV), which are determinants of viral host range. The prevailing model for E3 function is that it inhibits PKR through the non-specific sequestration of double-stranded (ds) RNA.