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Articles by Chris Drakeley
A planetary health approach is needed to manage the wider impacts of rice production
Rice production is critical to global food security, but it has unintended consequences: water stress, greenhouse gas emissions and disease-vector mosquitoes and snails, usually addressed by separate sectors in isolation. A planetary health approach that integrates agriculture, water, climate, ecosystems and health can identify rice growing practices that deliver benefits across these domains.
The transmission-blocking dynamics of Plasmodium falciparum sexual-stage antibody responses in a six-year cohort of Ugandan children and adults
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Abstract Individuals naturally infected with Plasmodium can develop antibodies against the parasite’s sexual stages that may inhibit onward transmission when ingested they are during a mosquito vector’s blood meal. Our study reports immune signatures and longitudinal dynamics of naturally occurring transmission-reducing activity (TRA) in a Ugandan cohort.
By Sara Blanken, Patience Nayebare, Gerine Nijman, Karina Teelen, Rianne Stoter, Geert-Jan van Gemert, Wouter Graumans, Tate Oulton, Catriona Patterson, Abdoulie Drammeh, Judith M. Bolscher, Lauren Cohee, Sanjai Kumar, Noah Sather, Alvaro Molina-Cruz, Emmanuel Arinaitwe, Moses Kamya, Koen J. Dechering, Grant Dorsey, Chris Drakeley, Matthijs M. Jore, Teun Bousema, William Stone, Jonathan Briese, Marloes de Bruijni
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Nature
Verified
Continental-scale genomic surveillance of Plasmodium falciparum malaria across sub-Saharan Africa with rapid nanopore sequencing
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Abstract In sub-Saharan Africa, continental-scale genomic surveillance of Plasmodium falciparum malaria is needed to track the spread of drug and diagnostic resistance, as well as monitor parasite evolutionary responses to vaccine rollout. Yet continental-scale implementation is hindered by a lack of genomic approaches suitable for local laboratories, and the vastness of the continent. Here, we initiate a decentralised scale-up of P.
By Mulenga Mwenda, Welmoed van Loon, Brenda Mambwe, Amy Gaye, Salma Suliman, Djiby Sow, Bassirou Ngom, Arsène Zongo, Sheila Otieno, Bixa Ogola, Manuela Carrasquilla, Torsten Feldt, Tafese Beyene Tufa, Rafael Oliveira, Christina Ntalla, Oumarou Ouédraogo, Kephas Otieno, Adekunle O. Olowe, Marley Gibbons, Chris Drakeley, Frank P. Mockenhaupt, Issiaka Soulama, Daouda Ndiaye, Olusola Ojurongbe, Simon Kariuki, Jonathan Schultz, Moonga B. Hawela, Daniel Bridges, Jason Hendry, Karolina Mosler, Bernd Bohmeier, Miriam Chomba, Adedolapo Olorunfemi, Nassandba Julien Yanogo, Fiyinfoluwa Ojeniyi, Etilé A. Anoh, Vincent Achi, Carol Chiyesu, Moussa Niangaly, Dagaga Kenea Goboto, Emma Schallenberg, Yuhana Sogoba, Oluyinka Opaleye, Grit Schubert
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Nature
Verified
Characterizing trachoma elimination using serology - Nature Communications
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Abstract Trachoma is targeted for global elimination as a public health problem by 2030. Measurement of IgG antibodies in children is being considered for surveillance and programmatic decision-making. There are currently no programmatic guidelines based on serology, which represents a generalizable problem in seroepidemiology and disease elimination.
By Everlyn Kamau, Pearl Anne Ante-Testard, Sarah Gwyn, Seth Blumberg, Kristen Aiemjoy, Robin Bailey, Chris Drakeley, Emma M Harding-Esch, Amir B. Kello, Andres G. Lescano, Stephanie J Migchelsen, John M. Nesemann, Kristen K Renneker, Chrissy h. Roberts, Dorothy Yeboah-Manu, Jeremy Keenan, Thomas M. Lietman, Anthony W. Solomon, Willie Pomat, Ariktha Srivathsan, Karana Wickens
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Nature
Verified
New insights on malaria parasite adaptation yielded by samples archived for more than 50 years
Abstract Understanding evolution of human pathogens requires looking beyond effects of recent interventions or known epidemiological changes. To study malaria parasites prior to widespread drug selection, Plasmodium falciparum genome sequences were analysed from the oldest set of archived research samples yet identified, placental blood collected in the Gambia between 1966 and 1971.
Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics
Introduction Plasmodium vivax is a major cause of malaria in tropical regions. In 2022, its burden was estimated at 6·9 million clinical cases globally.1 P vivax malaria is characterised by the ability of the parasite to form dormant liver stages (known as hypnozoites), which can reactivate weeks to months after the initial infection to cause recurrent episodes of parasitaemia (known as relapses).
Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats - Nature Communications
Abstract Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malaysian Borneo, but HPAI has circulated in poultry and migratory avian species transiting through the region. Recent deforestation in coastal habitats in Malaysian Borneo may increase the proximity between humans and migratory birds.
Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects - Nature Medicine
Abstract Malaria-elimination interventions aim to extinguish hotspots and prevent transmission to nearby areas.
Parasitological and clinical effects of malaria chemoprevention with sulfadoxine-pyrimethamine in pregnant women from southern Mozambique
Highlights • Carriage of quintuple SP resistance markers is almost fixated in Southern Mozambique. • In this context, IPTp-SP still retains parasitological and clinical effects. • Both malaria-related and unrelated mechanisms can contribute to IPTp-SP effectiveness. • Late ANC attendance and suboptimal number of IPTp-SP doses are still major barriers.
Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023
Loading metrics Open Access Peer-reviewed Research Article Citation: Garcia KKS, Soremekun S, Abrahão AA, Marchesini PB, Drakeley C, Ramalho WM, et al. (2024) Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023. PLOS Glob Public Health 4(1): e0002845.
Record Linkage for Malaria Deaths Data Recovery and Surveillance in Brazil
1. Introduction Brazil’s health surveillance system boasts a rich repository of epidemiological data stored in various Health Information Systems (HISs).
Evidence for a role of Anopheles stephensi in the spread of drug- and diagnosis-resistant malaria in Africa - Nature Medicine
Abstract Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas where malaria resurged suggested a possible role in causing malaria outbreaks. Here, using a prospective case–control design, we investigated the role of An. stephensi in transmission following a malaria outbreak in Dire Dawa, Ethiopia in April–July 2022.
Zoonotic malaria requires new policy approaches to malaria elimination - Nature Communications
Increasing numbers of human zoonotic malaria cases are reported globally. Current malaria control measures cannot eliminate transmission from wildlife reservoirs, leaving many countries with no pathway to malaria elimination certification. New policies are needed to redefine elimination goals and certification. Defining malaria elimination A world free of malaria is the declared vision of the global health community1.
Detecting temporal and spatial malaria patterns from first antenatal care visits - Nature Communications
Abstract Pregnant women attending first antenatal care (ANC) visits represent a promising malaria surveillance target in Sub-Saharan Africa. We assessed the spatio-temporal relationship between malaria trends at ANC (n = 6471) and in children in the community (n = 3933) and at health facilities (n = 15,467) in southern Mozambique (2016–2019). ANC P.
Global patterns of submicroscopic Plasmodium falciparum malaria infection: insights from a systematic review and meta-analysis of population surveys
ArticlesVolume 2, Issue 8e366-e374Open access aMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK bPATH, Seattle, WA, USA cDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands dDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK Publication History: Published May 25, 2021 DOI:...
Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
Research Overdiagnosis of...
Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo
Abstract Human movement into insect vector and wildlife reservoir habitats determines zoonotic disease risks; however, few data are available to quantify the impact of land use on pathogen transmission. Here, we utilise GPS tracking devices and novel applications of ecological methods to develop fine-scale models of human space use relative to land cover to assess exposure to the zoonotic malaria Plasmodium knowlesi in Malaysian Borneo.
Mitochondrial variation in subpopulations of Anopheles balabacensis Baisas in Sabah, Malaysia (Diptera: Culicidae)
Anopheles balabacensis, the primary vector of Plasmodium knowlesi in Sabah, Malaysia, is both zoophilic and anthropophilic, feeding on macaques as well as humans. It is the dominant Anopheles species found in Kudat Division where it is responsible for all the cases of P. knowlesi. However there is a paucity of basic biological and ecological information on this vector.
malERA: An updated research agenda for malaria elimination and eradication
Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the “Global Technical Strategy” and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated.
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