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Christina Hill

As seen in: Cell Press, Genes and Development Journal

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Articles

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation

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By Aaron T Crain, Christina Hill, Mai Anh Huynh
| Genes and Development Journal
1,2,3,4,7 1Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 USA; 2Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 USA; 3Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 USA; 4Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 USA; 5Division of Chemical Biology and...
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Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms

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By Alexis Stutzman, Christina Hill, Robin Armstrong, Riya Gohil
| Cell Press Verified
Highlights • Drosophila euchromatin spatially segregates from pericentromeric heterochromatin • Pericentromeric heterochromatin maintenance requires H3K9 and the HP1a chromodomain • HP1a binding to H3K9 ensures a strong pericentromeric heterochromatin boundary • Pericentromeric heterochromatin still self-associates despite loss of H3K9-bound HP1a Summary Whether and how histone post-translational modifications and the proteins that bind them drive 3D genome organization remains unanswered.
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