Christine Hinz

Highlights • In fasting compared to fed subjects, plasma IL-1β is lower and arachidonic acid (AA) is higher • Exogenous AA impairs NLRP3 inflammasome activity in human and mouse macrophages • AA inhibits phospholipase C and reduces JNK stimulation and hence NLRP3 activity Summary Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the mechanistic basis for this is unclear.

With a portfolio of boutique properties set on some of New York state’s most stunning waterfronts, Harbor Hotel Collection, owned and operated by Hart Hotels, offers small groups singular meeting experiences and a range of one-of-a-kind activities perfectly suited for corporate, association and SMERF groups.

Abu Dhabi, the oil-rich capital of the United Arab Emirates, rises with a skyline of striking modern architecture where the desert sands of the Arabian Peninsula meet the azure waters of the Persian Gulf. Made up of a swath of desert on the Arabian Peninsula, a ‘main island’ that is the city’s center, and outer islands developed for leisure, luxury, and culture, I’m on a quest to experience all Abu Dhabi has to offer, with a beach, city, and desert experience. Jumeirah at Saadiyat Island Resort.