Christine Olson on Muck Rack

Christine Olson

As seen in: Winona Daily News, Nature, Wiley Online Library, Cell Metabolism, Cell Press, Cell Reports, Taste Of Home, Sarasota Herald-Tribune
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Articles

Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity

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By Kai Trepka, Than kyaw, Christine Olson, Wesley A Kidder
| biorxiv.org
Abstract Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Herein, we demonstrate the utility of a more comprehensive approach to studying drug toxicity through longitudinal study of the human gut microbiome during colorectal cancer (CRC) treatment ( NCT04054908) coupled to cell culture and mouse experiments.
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Projecting Global Mercury Emissions and Deposition Under the Shared Socioeconomic Pathways

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By David G. Streets, Colin Thackray, Christine Olson, Benjamin M. Geyman
| Wiley Online Library
1 Introduction Mercury (Hg) is a naturally occurring element, but human activities such as mining and fossil-fuel combustion have released approximately 1.5 Tg of Hg from stable geologic reservoirs to the atmosphere, land, and water over the past 500 years (1510–2010) (Streets et al., 2019a). This has significantly altered the natural biogeochemical Hg cycle (Geyman et al., 2023; Streets et al., 2019a) and adversely affected the health of exposed humans and wildlife (Basu et al., 2023).
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Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice

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By Gregory Lum, Christine Olson, Jorge Paramo, Joyce H. Matsumoto
| Cell Reports
Highlights • Colonizing mice with KD-associated human gut microbes increases seizure resistance • Human donor and mouse recipients share select metagenomic and metabolomic features • Mice colonized with KD-associated gut microbes exhibit altered brain transcriptomes • Multi-omic analysis shows candidate microbial key drivers of seizure protection Summary The gut microbiome modulates seizure susceptibility and the anti-seizure effects of the ketogenic diet (KD) in animal models, but whether...
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