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Articles by Christopher Morrow
Discussing a Diagnosis of Alzheimer’s Disease With Patients and Caregivers
Transcript This transcript has been edited for clarity. Brent P. Forester, MD, MSc: Hi, everybody. My name is Dr Brent Forester. Welcome to our Care Cues conversation today on Alzheimer's disease. We are going to focus on conversations with patients about the options that are out there for treatment. I'm excited today to be joined by my colleague, Dr Chris Morrow, from Johns Hopkins University. Christopher B. Morrow, MD, MHS: Thanks so much, Dr Forester.
Christopher Morrow
259 Prospect Plains Rd, Bldg H Cranbury, NJ 08512
Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment
Autonomic dysfunction is recognized as a contributor to cognitive impairment in patients with Parkinson's disease (PD).1 Cardiovascular autonomic failure is associated with a greater risk for phenoconversion in isolated rapid eye movement sleep behavior disorder (RBD).2 Although the relationship between orthostatic hypotension (OH), a manifestation of autonomic dysfunction, and cognitive decline has been observed after PD onset,3 this relationship remains poorly understood during the...
Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia
Supporting Information Filename Description pcn13810-sup-0001-TableS1.docxWord 2007 document , 17.4 KB Table S1. Mixed-effects regression of neuropsychiatric symptoms (NPS) persistence. References 1, , et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011; 134: 2456–2477. 2, , , , .
Orthostatic Hypotension and Cognition in Lewy Body Disorders: On Promising Tides
Relevant conflicts of interest/financial disclosures: The authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this letter.
The Effect of Dysautonomia on Motor, Behavioral, and Cognitive Fluctuations in Parkinson's Disease
Supporting Information Filename Description mds30044-sup-0001-supinfo.docxWord 2007 document , 31.6 KB Table S1. Linear regression model using the total SCOPA-AUT score (exposure variable) and change scores as continuous variable. Table S2. Dysautonomia on medication-induced changes in motor and non-motor features: raw data on change in scores. Figure S1.
Neuropsychiatric Symptoms Cluster and Fluctuate Over Time in Behavioral Variant Frontotemporal Dementia
Preliminary analysis from this work was presented as an abstract at the ISFTD Conference in Amsterdam, NL on September 21 2024. CM was funded my KL2TR003099 and is now funded by K23AG088248. AP is funded by NIA/NIH (K23AG059891). JR is funded by NIA/NIH K23AG059888, AlzOut, Shenandoah fund and Jon and Gale Love Alzheimer's fund and is a site PI for clinical trials sponsored by Eli-Lilly and Eisai and a consultant and speaker for Roon Health, Inc.
The effect of dysautonomia on motor, behavioral and cognitive fluctuations in Parkinson disease
The authors have declared no competing interest. https://reporter.nih.gov/search/AyzaeM4JmESgTldq1ht9gA/project-details/8634954 Dr. Greg Pontone and the study described in this manuscript was funded by the NIH/NIA as part of a K23 award (K23 AG044441-01A1). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
La asociación entre el uso de antidepresivos y el trastorno del control de los impulsos en la enfermedad de Parkinson
Objetivos Examinar si el inicio de un antidepresivo está asociado con el desarrollo de un trastorno de control de impulsos (CIE) en pacientes con enfermedad de Parkinson (EP). Diseño Realizamos un análisis retrospectivo utilizando datos de la Iniciativa de Marcadores de Progresión de Parkinson (PPMI). Se utilizaron pruebas de Mann-Whitney de dos muestras para la comparación de variables continuas y pruebas de Pearson χ² para variables categóricas.
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC - Communications Biology
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader of ERα. In vitro studies with this PROTAC demonstrate excellent ERα degradation and ER antagonism in ER+ breast cancer cell lines. However, upon dosing the compound in vivo we observe an in vitro-in vivo disconnect.
Autofluorescence is a biomarker of neural stem cell activation state
Neural stem cells (NSCs) must exit quiescence to produce neurons; however, our understanding of this process remains constrained by the technical limitations of current technologies. Fluorescence lifetime imaging (FLIM) of autofluorescent metabolic cofactors has been used in other cell types to study shifts in cell states driven by metabolic remodeling that change the optical properties of these endogenous fluorophores.
Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change Across the Disease Course
Preliminary analysis from this work was presented as an abstract at the ACTS Conference in Washington, DC on April 18 2023. CM is funded my KL2TR003099. AP is funded by NIA/NIH (K23AG059891). JR is funded by NIA/NIH K23AG059888, AlzOut, Shenandoah fund and Jon and Gale Love Alzheimer's fund and is a site PI for clinical trials sponsored by Eli-Lilly and Eisai and a consultant and speaker for Roon Health, Inc.
Most Doctors Are ‘Very’ Concerned About Health Care Consolidation
Op-Med is a collection of original articles contributed by Doximity members. A recent Doximity poll of over 2,200 clinicians showed that 88% are concerned about the rise in hospital and practice consolidation.
Patients Are Asking About Marijuana. Can We Give Them Answers?
Op-Med is a collection of original articles contributed by Doximity members. I’ll never forget his eyes. The way they darted back and forth, unable to settle, chasing some unseen terror. Or the way he tried to explain his thoughts – getting stuck – ideas coming out of sequence, losing their connection mid-sentence. Then finally, the silent tears tracing the outline of his face when I mentioned a diagnosis of schizophrenia.
How Drug Manufacturers Keep Hold of Market Exclusivity
Op-Med is a collection of original articles contributed by Doximity members. There is a fine balance between incentivizing medical innovation and managing associated health care costs, two forces that often are in opposition with one another. Drug patents are a perfect example of this. A brand name drug manufacturer retains patent exclusivity for a set duration of time before cheaper generic substitutes enter the market.
Should Physicians Invest Even When They Have Student Loans?
Op-Med is a collection of original articles contributed by Doximity members. This content is provided for informational purposes only and does not constitute financial, tax, legal or other advice. Any strategies discussed should not be undertaken by any individual without prior consultation with an appropriate professional for the purpose of assessing whether such strategies are suitable for their particular situation. Should physicians invest even when they have student loans?
Banishing the Doctor in Me
Op-Med is a collection of original articles contributed by Doximity members. I remember at the start of medical school they told us that we were not simply learning a profession, we were acquiring a new identity. Once a physician, always a physician. Indeed, I find it difficult to separate my physician self from my personal self — to turn off the doctor in me. If I find a treatment that works, I want to share it with my loved ones. Maintaining a friendship with a patient can be difficult and fraught.
Matching Into Surgery: Advice from the 2022 Cycle
Op-Med is a collection of original articles contributed by Doximity members. I am grateful to have matched into orthopaedic surgery residency, especially as a DO. This year’s Match demonstrated increasing competitiveness for all surgical applicants. For orthopaedic surgery, there were 1,470 applicants for 875 positions, resulting in an overall 60% match rate. Among the 205 DO applicants, only 111, or 54%, were matched.
How Embracing My Shame Is Making Me a Better Doctor
Op-Med is a collection of original articles contributed by Doximity members. One of my children’s favorite pastimes is itemizing my personal failings. And that sweltering August Sunday in 2021 holds pride of place in our family’s oral history, remembered and reexamined, elaborated and expanded, assuming grotesque proportions with each retelling.
Operating, Literally, In High-Stress Situations
Op-Med is a collection of original articles contributed by Doximity members. In medical school, we are taught how to help bodies adapt and work through stressful situations. One of the most powerful lessons I learned in medical school was how to treat an acute ischemic stroke. When there is a blockage in a blood vessel in the brain, blood can no longer pass through and oxygenate the brain. If the blockage is not cleared in a timely fashion, we may lose all of these important things that make us, us.
My Partner of 20 Years Fired Me From My Own Clinic
Op-Med is a collection of original articles contributed by Doximity members. I grabbed the photo off the wall. The one of me as a surfer, not a doctor. The Indian Ocean’s azure plate. The pale sky. The bending wave like liquid glass before it cools. I stared at the crouching shape beneath the curl that was once me, seemingly in control despite the wave’s chaos and rage. Funny, the different versions of ourselves we wear like suits, the varied archetypes of our changing skins.
Why I Stopped Typing in Clinic
Op-Med is a collection of original articles contributed by Doximity members. Do you remember the first patient you ever interviewed? That feeling of knocking on the door and then catching your breath as you walk in and see a person lying in a hospital gown waiting for you. For me it was a few months into my first year of medical school. I had just finished struggling my way through first-year anatomy when my first patient interview was scheduled.
I Thought Intense Exercise Was Helping Me, Not Hurting Me
Op-Med is a collection of original articles contributed by Doximity members. There’s nothing quite like the feeling of your heart beating out of control. It’s a strange mix of panic and calm – as if the lack of oxygen to your brain causes those circuits to cross and your body’s not sure whether to run or go to sleep. It’s a calm panic – like watching a building collapse without realizing that you are the building.
Survive Residency with These 5 Steps
Op-Med is a collection of original articles contributed by Doximity members. The graduation from medical student to physician is transformative on many levels. There is the physical transformation of receiving a longer white coat, and the responsibilities that come with it. There is the metaphysical transformation of finally being called “doctor” (and maybe an initial delay in response because you’re not used to your new title).
Op-Med is a collection of original articles contributed by Doximity members. The patient was not unusual. It was a Wednesday, several years ago in late October. The wet, autumn weather had ushered in a flurry of patients with the same nagging symptoms: sneezing, runny nose, headache, sore throat, sinus pressure…. I knew well the constellation of complaints attached to seasonal allergies — I even had them myself.
Why My Patient History Includes Asking About Pets
Op-Med is a collection of original articles contributed by Doximity members. As I stumble into yet another year of pandemic malaise, it’s easy to feel discouraged by the state of the world. But despite all that is challenging in this new year, there’s a familiar comfort at my side that didn’t exist in my pre-COVID world — the now grown puppy that joined my family a year ago and is now plastered to my side whenever I’m at home.
Supplements Are Simply Medications Without FDA Oversight
Op-Med is a collection of original articles contributed by Doximity members. As a urologist, I have heard my fair share of questions about all-natural remedies for everything, including the treatment of urinary tract infections, cancer, and erectile dysfunction. If I had to guess, I spend at least 3-4 hours per week (which feels like 4-5 hours per day) trying to find respectful ways to answer the same question: “Is there an all-natural remedy that I can take for my medical problem?
7 Ways for Doctors to Create Passive Income in Medical Practice
Op-Med is a collection of original articles contributed by Doximity members. The key to building wealth is to convert active income into passive income. As doctors pursuing financial freedom, in essence, your goal is to create passive income.
One Splits into Two, Two into Three
Op-Med is a collection of original articles contributed by Doximity members. This is part of the Medical Humanities series on Op-Med, which showcases creative work by Doximity members. Do you have a creative work related to your medical practice that you’d like to share? Send it to us here. What inspired you to create this painting? The hours after [my] delivery had been chaotic. There were the usual complications, and then some.
Medical Records are Essential. Patient Stories Can Make Them Meaningful, Too
Op-Med is a collection of original articles contributed by Doximity members. Here I am again, at the end of a long day of clinic. Orders placed, patients seen, phone calls made. It’s time to settle in and finish the notes. It’s time to write these stories. Today there is a short story about a healthy pregnancy and a happy baby. We mostly talked about how newborn babies don’t sleep well and how it will get better.
4 Benefits That Might Actually Make Clinicians Stay
Op-Med is a collection of original articles contributed by Doximity members. Several years ago, before the stress of a medical career sprinkled gray hairs across my beard, I boarded an airplane for an all-expenses paid trip to a medium-sized city in the Midwest. I felt like a king. A driver and private car waited to take me to a five-star hotel where a steak dinner and other expenses were covered by my future employer.
What Clinicians Can Learn From the “Free Britney” Movement
Op-Med is a collection of original articles contributed by Doximity members. Sitting alone after a long day in the hospital a few months ago, I lazily clicked a link to a transcript of Britney Spears testifying about her conservatorship. I had been loosely following the case, vaguely aware of the “Free Britney Movement,” but not keyed into the details of the situation. I clicked the link out of curiosity and boredom, not expecting anything shocking.
Why We Need to Rethink Disparities Research
Op-Med is a collection of original articles contributed by Doximity members. Over the past several years, a new branch of research has emerged highlighting disparities in health care associated with race, ethnicity, gender, sexual orientation, rural residency, lower socioeconomic status, etc. A PubMed query for the term ‘health disparities’ yields more than 8,800 results in 2021, only to be outdone by 2020, when more than 10,000 papers addressing this theme were published.
Why I’m Laughing About Beets In the Exam Room
Op-Med is a collection of original articles contributed by Doximity members. This is part of the Medical Humanities series on Op-Med, which showcases creative work by Doximity members. Do you have a creative work related to your medical practice that you’d like to share? Send it to us here. Beets It’s good to see you again Mrs. Webster You too doctor How’s the kids? Oh, just fine. Jimmy is in soccer now. Brad is on the swim team. And the Judge? The same, but I can’t get him on that diet you recommended.
The Push and Pull of Birth and Loss
Op-Med is a collection of original articles contributed by Doximity members. 5:30 am. The halls of the hospital are empty, the night shift ending, the sun peeking through the windows. I arrive at the residents’ workstation on the Labor & Delivery floor, tired, nervous, and excited. I’m on my obstetrics/gynecology rotation, my first month on the wards during my third year of medical school.
Athletes Can Ask for Mental Health Help. Why Can’t We?
Op-Med is a collection of original articles contributed by Doximity members. Sitting with my team before rounds early this summer, a notification popped up on my phone that resonated through the room – “Simone Biles withdraws from team all-around final due to mental health concerns.” In a room of psychiatry trainees, this news was both surprising and close to home. We sat with our thoughts for a moment, and then got on with our day on the inpatient ward.
Daily Legal News
Bankruptcy 2021-50193 Case Number 2021-50193 Date Filed Tuesday, February 9, 2021 Chapter & Region 7 & 475 Debtor Christopher Edward Morrow 3866 Hile Road Stow, OH 44224 Joint Debtor Tami Lisette Morrow About your information and the public record.
New Swiss Rates Spell More Bad News for Russia
New Swiss Rates Spell More Bad News for Russia Russian elites squeezed by pressure from the uncertainty surrounding the enormous decline in oil prices and the continuing drop in value of the ruble have been dealt another blow after Switzerland unexpectedly announced last week that it would abandon the cap on the Swiss franc’s rate against the euro. The ruble has plummeted 55 percent against the US dollar since Western sanctions against Russia began after they annexed Crimea.
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
Highlights • Mammalian NSCs utilize vimentin-caged aggresomes to recover proteostasis • Vimentin is required for proteasome localization to the aggresome in NSCs • Quiescent NSCs upregulate vimentin protein and utilize aggresomes during activation • Vimentin knockout in NSCs impairs proteostasis recovery and delays quiescence exit Summary Maintaining a healthy proteome throughout life is critical for proper somatic stem cell function, but the complexities of the stem cell response to...
Newly identified cellular trash removal program helps create new neurons
An immunofluorescence image of a region of the brain called the dentate gyrus within the hippocampus which is one of two places that neural stem cells reside in a rodent brain. In this image you can see many neural stem cells in the brain labeled by vimentin in red and Sox2, a marker for cells that are self-renewing, in cyan.
‘Minor Modification’ Luxury Towers in Two Bridges Halted for Now
Christopher Morrow & Indypendent Staff Jun 10 Community groups opposing the construction of high-end luxury towers in Manhattan’s Two Bridge’s neighborhood won an injunction against the development in court last week. The development team, however, says it will challenge the restraining order and still plans to go forward with the project.
Prefix hijacking by AS20115
Re: Do you have INOC-DBA set up? (was: Re: PCH.net questions and thoughts - Re: Prefix hijacking by AS20115) Matthew Walster (Sep 29)
Prefix hijacking by AS20115
nanog mailing list archives Re: Prefix hijacking by AS20115 From: Christopher Morrow <morrowc.lists () gmail com>Date: Tue, 29 Sep 2015 00:28:54 -0400On Mon, Sep 28, 2015 at 11:59 PM, Bob Evans <bob () fiberinternetcenter com> wrote: That's something I would do. Announce announce and keep adding ports until I hit a 10 Gig port worth of traffic or saw it fixed. Be sure to put in a blackhole route for the prefixes.
Prefix hijacking by AS20115
nanog mailing list archives Re: Prefix hijacking by AS20115 From: Christopher Morrow <morrowc.lists () gmail com>Date: Tue, 29 Sep 2015 02:15:57 -0400On Tue, Sep 29, 2015 at 2:04 AM, Bob Evans <bob () fiberinternetcenter com> wrote: On Mon, Sep 28, 2015 at 11:59 PM, Bob Evans <bob () fiberinternetcenter com> wrote: That's something I would do. Announce announce and keep adding ports until I hit a 10 Gig port worth of traffic or saw it fixed. Be sure to put in a blackhole route for the prefixes.
CHP website returning 503
Re: CHP website returning 503 Christopher Morrow (Sep 27)
Question re session hijacking in dual stack environments w/MacOS
Re: Question re session hijacking in dual stack environments w/MacOS
Verizon Wireless LTE/4G and SIP Header Manipulation
nanog mailing list archives Re: Verizon Wireless LTE/4G and SIP Header Manipulation From: Christopher Morrow <morrowc.lists () gmail com>Date: Tue, 22 Sep 2015 15:51:02 -0400On Tue, Sep 22, 2015 at 12:22 PM, Christopher Morrow <morrowc.lists () gmail com> wrote: On Tue, Sep 22, 2015 at 12:03 PM, Mark Stevens <manager () monmouth com> wrote: Hi All, Has anyone seen that something (most likely an alg) on Verizon's LTE/4G network is rewriting SIP headers,in particular From Tag identifiers?
Verizon Wireless LTE/4G and SIP Header Manipulation
Re: Verizon Wireless LTE/4G and SIP Header Manipulation
Verizon Wireless LTE/4G and SIP Header Manipulation
Hi All, Has anyone seen that something (most likely an alg) on Verizon's LTE/4G network is rewriting SIP headers,in particular From Tag identifiers? We cannot make a SIP call from our cellphones (using cellular data) beyond 30 seconds because the TAGs are rewritten and the destination Asterisk server drops the call because of this.
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