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Clara Casey

As seen in: Nature
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Articles by Clara Casey

Single-cell atlas of transcriptomic vulnerability across brain disorders

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By Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse, Gabriel Hoffman, Seon S. Kinrot, Xinyi Wang, Prashant N. M, Milos Pjanic, Tereza Clarence, Deepika Mathur, David Burstein, Karen Therrien, Aram Hong, Clara Casey, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Jennifer Monteiro Fortes, Sarah Murphy, Pavel Katsel, Pavan K. Auluck, Lisa Barnes, Stefano Marenco, David Bennett, PsychAd Consortium, Lars Jensen, Kiran Girdhar, Georgios Voloudakis, Vahram Haroutunian, Jaroslav Bendl, John F. Fullard, Panos Roussos, Fotios Tsetsos
| Nature Verified
Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2.
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Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

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By Hui Yang, Tereza Clarence, Madeline Scott, Xinyi Wang, Prashant N. M, Milos Pjanic, Sanan Venkatesh, Aram Hong, Clara Casey, Sarah Murphy, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Alexander Yu, PsychAd Consortium, Nadejda M. Tsankova, Pavan K. Auluck, Stefano Marenco, Vahram Haroutunian, Georgios Voloudakis, Jaroslav Bendl, Colleen A. McClung, Donghoon Lee, John F. Fullard, Gabriel Hoffman, Kiran Girdhar, Panos Roussos
| Nature Verified
Abstract The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal ageing and its relationship to psychiatric and neurodegenerative disorders.
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Single-nucleus transcriptome-wide association study of human brain disorders

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By Sanan Venkatesh, Roman Kosoy, Zhenyi Wu, Christian Dillard, Prashant N. M, David Burstein, Deepika Mathur, Chris Chatzinakos, Bukola Ajanaku, Fotis Tsetsos, Biao Zeng, Sonali Gupta Verified, Rachel Bercovitch, Aram Hong, Clara Casey, Marcela Alvia, Zhiping Shao, Stathis Argyriou, Karen Therrien, PsychAd Consortium, Tim B. Bigdeli, Pavan K. Auluck, David Bennett, Stefano Marenco, Vahram Haroutunian, Kiran Girdhar, Jaroslav Bendl, Donghoon Lee, John F. Fullard, Gabriel Hoffman, Georgios Voloudakis, Panos Roussos, Marios Anyfantakis
| Nature Verified
Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging1. Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influence gene expression in specific cell types2,3,4,5.
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Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease

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By Donghoon Lee, James Vicari, Christian Porras, Collin Spencer, Milos Pjanic, Xinyi Wang, Seon S. Kinrot, Philipp Weiler, Roman Kosoy, Jaroslav Bendl, Prashant N. M, Konstantina Psychogyiou, Periklis Malakates, Evelyn Hennigan, Jennifer Monteiro Fortes, Shiwei Zheng, Karen Therrien, Deepika Mathur, Steven Kleopoulos, Zhiping Shao, Stathis Argyriou, Clara Casey, Kristin G. Beaumont, Robert Sebra, Christopher P Kellner, David Bennett, Guo-Cheng Yuan, Georgios Voloudakis, Fabian J. Theis, Vahram Haroutunian, Gabriel Hoffman, John F. Fullard, Panos Roussos, Marcela Alvia, Aram Hong
| Nature Verified
Abstract Myeloid cells, including microglia and perivascular macrophages, are central to Alzheimer’s disease (AD) neurobiology, yet their role remains incompletely understood. We profiled 832,505 human myeloid cells from the prefrontal cortex of 1,607 donors spanning the lifespan and showing varying degrees of AD neuropathology. We delineated six subclasses comprising 13 transcriptionally distinct subtypes and identified adaptive changes associated with aging and AD progression.
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Single-nucleus analysis of the adult human olfactory epithelium uncovers shared neurogenesis programs with the brain

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By John F. Fullard, Claire Coleman, Xinyi Wang, Ayako Kawatake-Kuno, Steven Kleopoulos, Samuel DeMaria, Jaroslav Bendl, Pengfei Dong, Panos Roussos, Evelyn Hennigan, Clara Casey, Stathis Argyriou, Alfred Marc Iloreta
| Nature Verified
Abstract Neurogenesis, a critical process implicated in diverse brain disorders, is greatly diminished in the adult human brain, complicating direct investigations into its mechanistic role in disease. In the olfactory epithelium (OE), olfactory sensory neurons (OSNs) maintain homeostasis via continual neurogenesis throughout life, providing a niche to investigate neurogenesis in vivo.
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