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Articles

Biological insights into schizophrenia from ancestrally diverse populations

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By Tim B. Bigdeli, Chris Chatzinakos, Jaroslav Bendl, Peter Barr, Sanan Venkatesh, Bryan R. Gorman, Tereza Clarence, Giulio Genovese, Conrad Iyegbe, Roseann E. Peterson, Sergios-Orestis Kolokotronis, David Burstein, Jacquelyn L. Meyers, Yuli Li, Sundar Natarajan, Michael Francis, Nallakkandi Rajeevan, Kei-Hoi Cheung, Lynn E. DeLisi, Thomas R. Kosten, Hongyu Zhao, Eric Achtyes, Peter Buckley, Dolores Malaspina, Douglas S Lehrer, Mark Rapaport, David L Braff, Michele Pato, Ayman H. Fanous, Carlos N. Pato, PsychAd Consortium, Grant D. Huang, Sumitra Muralidhar, J. Michael Gaziano, Saiju Pyarajan, Kiran Girdhar, Donghoon Lee, Gabriel Hoffman, Mihaela Aslan, John F. Fullard, Georgios Voloudakis, Philip Harvey, Panos Roussos
| Nature Verified
Abstract Schizophrenia and related psychoses occur in all human populations, with the highest rates of diagnosis among Black individuals and those of mainly African ancestry1. Decades of research have established a highly heritable and polygenic basis for schizophrenia, which is mostly shared across populations2,3,4. However, a recruitment bias towards European cohorts5 has led to discoveries that are poorly generalizable to African populations.
Open in Who Shared Issue with article?

Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution - Scientific Data

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By John F. Fullard, Donghoon Lee, Karen Therrien, Stefano Marenco, Kiran Girdhar, Vahram Haroutunian, Gabriel Hoffman, Georgios Voloudakis, Jaroslav Bendl, Prashant NM, PsychAd Consortium
| Nature Verified
Abstract Neurodegenerative diseases and serious mental illnesses often exhibit overlapping characteristics, highlighting the potential for shared underlying mechanisms. To facilitate a deeper understanding of these diseases and pave the way for more effective treatments, we have generated a population-scale multi-omics dataset consisting of genotype and single-nucleus transcriptome data from the prefrontal cortex of frozen human brain specimens.
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