Claudio Badía-Careaga on Muck Rack

Claudio Badía-Careaga

As seen in: Cell Press, Cell Reports
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Articles

Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis

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By Magali De Koninck, Itziar Cossío, Eleonora Lapi, Claudio Badía-Careaga
| Cell Reports Verified
Highlights • MEFs lacking STAG2 show reduced proliferation and mild cohesion defects • Stag2 loss in adult mice reduces fitness but does not increase tumor incidence • Stag2 KO embryos die by E10.5 with global developmental delay and malformed hearts Summary Cohesin mediates sister chromatid cohesion and 3D genome folding. Two versions of the complex carrying STAG1 or STAG2 coexist in somatic vertebrate cells.
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