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Abstract Acute respiratory failure (ARF) is common, exhibits variable outcomes, and arises from diverse causes that incompletely reflect underlying biology. Although the pandemic accelerated molecular investigation of ARF in COVID-19, whether these biologic signals generalize to ARF in hospital populations of varying etiology and severity remains unknown.
Plasma proteomics reveals shared biologic signatures of acute respiratory failure across etiology and severity in COVID-19 and non-COVID-19 cohorts
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Abstract Acute respiratory failure (ARF) is common, exhibits variable outcomes, and arises from diverse causes that incompletely reflect underlying biology. Although the pandemic accelerated molecular investigation of ARF in COVID-19, whether these biologic signals generalize to ARF in hospital populations of varying etiology and severity remains unknown.
By Neha A Sathe, Eric D. Morrell, Ian B. Stanaway, F. Linzee Mabrey, Sarah Holton, Carmen Mikacenic, George L Anesi, Clea R. Barnett, David Brett-Major, M. Broadhurst, J. Perren Cobb, Amy Irwin, Vishakha Kumar, Douglas P. Landsittel, Richard Lee, Janice Liebler, Karen Lutrick, Vikramjit Mukherjee, Radu Postelnicu, Leopoldo N Segal, Jonathan E. Sevransky, Avantika Srivastava, Timothy M. Uyeki, David L. Wyles, Laura Evans Verified, Pavan K Bhatraju, Mark M. Wurfel
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Nature
Verified
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
Keywords tissue-resident macrophages SARS-CoV-2 MA-10 Siglec-1 CD169 nerve- and airway-associated interstitial macrophages innate immunity disease tolerance immunoregulation interferons immunosuppression Get full text access Log in, subscribe or purchase for full access. References 1. Wei, X. ∙ Narasimhan, H. ∙ Zhu, B. ... Host Recovery from Respiratory Viral Infection Annu. Rev. Immunol. 2023; 41:277-300 2. Aegerter, H.
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Clea R.
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