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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Type 2 immune history trains lung macrophages for viral disease tolerance
Abstract Severe respiratory viral disease varies widely among individuals and often reflects immunopathology rather than inadequate pathogen control, suggesting that previous immune history can prime the lungs towards disease tolerance. Here we show that nerve- and airway-associated macrophages (NAMs), a subset of interstitial macrophages, expand ephemerally after type 2 inflammation induced by Nippostrongylus brasiliensis.
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
Keywords tissue-resident macrophages SARS-CoV-2 MA-10 Siglec-1 CD169 nerve- and airway-associated interstitial macrophages innate immunity disease tolerance immunoregulation interferons immunosuppression Get full text access Log in, subscribe or purchase for full access. References 1. Wei, X. ∙ Narasimhan, H. ∙ Zhu, B. ... Host Recovery from Respiratory Viral Infection Annu. Rev. Immunol. 2023; 41:277-300 2. Aegerter, H.
MAVS Signaling Is Required for Preventing Persistent Chikungunya Heart Infection and Chronic Vascular Tissue Inflammation
Abstract Chikungunya virus (CHIKV) infection has been associated with severe cardiac manifestations, yet, how CHIKV infection leads to heart disease remains unknown. Here, we leveraged both mouse models and human primary cardiac cells to define the mechanisms of CHIKV heart infection. Using an immunocompetent mouse model of CHIKV infection as well as human primary cardiac cells, we demonstrate that CHIKV directly infects and actively replicates in cardiac fibroblasts.
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