Eric Bartnicki

Keywords tissue-resident macrophages SARS-CoV-2 MA-10 Siglec-1 CD169 nerve- and airway-associated interstitial macrophages innate immunity disease tolerance immunoregulation interferons immunosuppression Get full text access Log in, subscribe or purchase for full access. References 1. Wei, X. ∙ Narasimhan, H. ∙ Zhu, B. ... Host Recovery from Respiratory Viral Infection Annu. Rev. Immunol. 2023; 41:277-300 2. Aegerter, H.

Abstract Chikungunya virus (CHIKV) infection has been associated with severe cardiac manifestations, yet, how CHIKV infection leads to heart disease remains unknown. Here, we leveraged both mouse models and human primary cardiac cells to define the mechanisms of CHIKV heart infection. Using an immunocompetent mouse model of CHIKV infection as well as human primary cardiac cells, we demonstrate that CHIKV directly infects and actively replicates in cardiac fibroblasts.

Highlights • KEAP1 mutations in lung cancer suppress anti-tumor CD103 DC and CD8 T cell responses • Hyperactivation of NRF2 is responsible for immune evasion in KEAP1-mutant tumors • Glutaminase inhibition can sensitize KEAP1-mutant tumors to immunotherapy Summary Lung cancer treatment has benefited greatly through advancements in immunotherapies. However, immunotherapy often fails in patients with specific mutations like KEAP1, which are frequently found in lung adenocarcinoma.