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Articles by Congcong Chen
Targeting the PRMT5-CBX8 axis overcomes dual barriers of CD8⁺ T cell exclusion and tumor stemness for sensitizing TNBC to anti-PD-1 therapy
Abstract The efficacy of immune checkpoint blockade in triple-negative breast cancer (TNBC) is limited by poor CD8⁺ T cell infiltration. Here, we demonstrate that tumor-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) drives CD8⁺ T cell exclusion, and we identify protein arginine methyltransferase 5 (PRMT5) as an important epigenetic regulator responsible for PCSK9 expression in TNBC.
Large-scale whole-genome sequencing reveals the landscape and health implications of de novo mutations
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Abstract De novo mutations (DNMs) are an important source of congenital diseases. With delayed parenthood and assisted reproductive technology (ART) use increasing, it is essential to elucidate how these reproductive factors influence DNMs and whether resulting mutations influence offspring health. Here we performed whole-genome sequencing of 24,030 individuals from 7,851 parent−offspring families, identifying 390,924 de novo single-nucleotide variants (dnSNVs).
By Na Qin, Juncheng Dai, Yue Jiang, Yuan Xie, Hong Lv, Jun L Zhou, Xiao Wang, Yangqian Jiang, Jiangbo Du, Yingjia Chen, Xianfeng Xu, Lingmin Hu, Congcong Chen, Ziye Xu, Jiawen Zhu, Yuhan Liu, Yu Wang, Ci Song, Yayun Gu, Tao Jiang, Bo Xu, Xiumei Han, Yuan Lin, Qingxia Meng, Xiufeng Ling, Hongxia Ma, Guangfu Jin, Cheng Wang, Hongbing Shen, Zhibin Hu
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Nature
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Nanomedicine for Benign Prostatic Hyperplasia: Pathological Axes and Translational Evidence
Back to Journals » International Journal of Nanomedicine » Volume 21 Authors Zeng B, Xie R, Chen C, Jin B, Yi C, He J, Zeng J, Xia X , Yang J Received 5 August 2026 Accepted for publication 27 September 2026 Published 8 October 2026 Volume 2026:21 646321 DOI https://doi.org/10.2147/IJN.S646321 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Sachin Mali Bozhi Zeng,1 Rujia Xie,1 Congcong Chen,1 Boyu Jin,1 Chengcheng...
Kinetic Trapping of Pressure-Induced Symmetry Breaking in Hybrid Metal Halides via Fluorine-Mediated Molecular Locking
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. CCDC 2523817-2523819 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre.
Hybrid smith predictor-neuroendocrine control for semi-active suspension of high-clearance agricultural sprayers
1. Introduction High-clearance self-propelled sprayer, as a key agricultural equipment in plant protection operation, plays a crucial role in maintaining food production safety and agricultural stable development [1]. The working environment of high-clearance sprayer is mostly bumpy and uneven field road, and the body is prone to produce large vibration, which affects the driving stability and ride comfort of the sprayer.
Engineering Efficient Circularly Polarized Luminescence in Copper(I) Iodides through Supramolecular Chirality Control
Cite Jump to ExpandCollapse ArticleDecember 2, 2025 Engineering Efficient Circularly Polarized Luminescence in Copper(I) Iodides through Supramolecular Chirality Control Click to copy article linkArticle link copied! Fangmei Fu Fangmei Fu Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China Congcong Chen Congcong Chen Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China Yutong Lin Yutong Lin Department of...
Chiral Two-Dimensional Cu-Pb Bromides: Circularly Polarized Luminescence and Pressure-Enhanced Optical Properties
ACS Nano Cite this: ACS Nano 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Tuning the Visible Circularly Polarized Luminescence in Highly Emissive Chiral Terbium and Europium Chlorides Chiral hybrid metal halides have become increasingly popular for their high structural tunability and exceptional optoelectronic properties. Incorporating rare-earth (RE) metals into the structural units and inheriting their pure emission characteristics are of great interests and importance.
Structure–Emission Property Relationship of Bilayer 2D Hybrid Perovskites
Introduction Click to copy section linkSection link copied! Hybrid organic–inorganic metal halide perovskites have emerged as a highly promising semiconductor material class suitable for a wide range of optoelectronic applications including solar cells, (1,2) light-emitting diodes, (3,4) X-ray scintillators, (5,6) and photodetectors.
Structure–Emission Property Relationship of Bilayer 2D Hybrid Perovskites
Introduction Click to copy section linkSection link copied! Hybrid organic–inorganic metal halide perovskites have emerged as a highly promising semiconductor material class suitable for a wide range of optoelectronic applications including solar cells, (1,2) light-emitting diodes, (3,4) X-ray scintillators, (5,6) and photodetectors.
Identification and Expression Profiling of the Cytokinin Synthesis Gene Family IPT in Maize
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Frontispiece: Orthogonal‐Group‐Controlled Site‐Selective I‐Branching of Poly‐N‐acetyllactosamine Chains Reveals Unique Binding Specificities of Proteins towards I‐Antigens
Dr. Congcong Chen Department of Chemistry and Center for Diagnostics & Therapeutics, Georgia State University, 50 Decatur Street SE, Atlanta, GA 30303, USA S. Bao, T. Shen, and C. Chen contributed equally to this work. Search for more papers by this author
Extended Cloud-TODIM Method for Multiple-Attribute Decision-Making Problems in Risk Reduction Schemes: Application in the Tailings Storage Facility Failure
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Development and validation of a transcription factor regulatory network‐based signature for individualized prognostic risk in lung adenocarcinoma
CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflict of interest. Supporting Information Filename Description ijc35375-sup-0001-Tables.xlsxExcel 2007 spreadsheet , 94.6 KB TABLE S1. Datasets used in this study. TABLE S2. The gene pair prognostic signature scGPS. TABLE S3. Survival analyses of early-stage samples with existing prognostic signatures in four datasets. ijc35375-sup-0002-Supinfo.pdfPDF document, 1.7 MB DATA S1. Supporting information. REFERENCES 1, , .
Facilitating Maize Seed Germination Under Heat Stress via Exogenous Melatonin
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The effect of ring substituent position on the structural and optoelectronic properties of novel quasi low-dimensional hybrid 2-, 3-, and 4-(bromomethyl)pyridinium lead bromides
The effect of ring substituent position on the structural and optoelectronic properties of novel quasi low-dimensional hybrid 2-, 3-, and 4-(bromomethyl)pyridinium lead bromides This work reports on the synthesis, crystal structure, morphology, and optoelectronic properties of novel quasi low-dimensional hybrid (bromomethyl)pyridinium crystalline phases (2-BrCH2PyH)Pb2Br5, (3-BrCH2PyH)PbBr3, and (4-BrCH2PyH)PbBr3.
Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer - Nature Communications
Abstract Genome-wide association studies have identified thousands of genetic variants associated with non-small cell lung cancer (NSCLC), however, it is still challenging to determine the causal variants and to improve disease risk prediction. Here, we applied massively parallel reporter assays to perform NSCLC variant-to-function mapping at scale. A total of 1249 candidate variants were evaluated, and 30 potential causal variants within 12 loci were identified.
Orthogonal‐Group‐Controlled Site‐Selective I‐Branching of Poly‐N‐acetyllactosamine Chains Reveals Unique Binding Specificities of Proteins towards I‐Antigens
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Lactobacillus rhamnosus GG attenuates depression‐like behaviour and cognitive deficits in chronic ethanol exposure mice by down‐regulating systemic inflammatory factors - Pan - 2024 - Addiction Biology - Wiley Online Library
1 INTRODUCTION Ethanol, commonly known as alcohol and one of the most widely abused substances in the world, is capable of crossing the blood–brain barrier (BBB) and causing damage to the brain.1 Ethanol has direct neurotoxicity to the brain, which can induce cognitive impairment, mental disorders and other problems.2, 3 Studies have shown that long-term exposure to ethanol can lead to neuroinflammation, which in turn can cause anxiety or depression-like behaviours.4 However, the mechanisms...
Tuning Spin-Polarized Lifetime at High Carrier Density through Deformation Potential in Dion-Jacobson-Phase Perovskites
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
The effect of precursor concentrations on the structure and optoelectronic properties of the quasi low-dimensional hybrid 2-methylpyridinium lead bromide crystalline phases
The effect of precursor concentrations on the structure and optoelectronic properties of the quasi low-dimensional hybrid 2-methylpyridinium lead bromide crystalline phases This work reports on the synthesis and optoelectronic properties of the crystalline phases [Pb2Br5][C6NH8] and [PbBr3][C6NH8] of 2-methylpyridinium lead bromide. Their synthesis is achieved through varying reactant concentrations.
Applied Sciences | Free Full-Text | Influence of Spherical Caverns on the Failure Characteristics of Neighboring Tunnels under True Triaxial Conditions: Insights from an Experimental Test and Discrete Element Simulation
4.4.2. Cavern-Existing Sample The step–stress–crack relationship of the numerical cavern-existing sample is shown in Figure 13. Five main steps, including tensile crack initiation, shear crack initiation, intermediate rock failure, start of splitting failure, and final peak stress status, were selected because of the prefabricated cavern; the appearance times of tensile, shear, and splitting failure are relatively earlier than the corresponding results of the cavern-free sample (Figure 10).
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer - Cell Death & Disease
Abstract Immune checkpoint blockade (ICB) is a promising treatment strategy for colorectal cancer (CRC) patients. However, most CRC patients do not response well to ICB therapy. Increasing evidence indicates that ferroptosis plays a critical role in immunotherapy. ICB efficacy may be enhanced by inducing tumor ferroptosis. Cytochrome P450 1B1 (CYP1B1) is a metabolic enzyme that participates in arachidonic acid metabolism. However, the role of CYP1B1 in ferroptosis remains unclear.
Convergent Chemoenzymatic Synthesis of O-GalNAc Rare Cores 5, 7, 8 and Their Sialylated Forms
Convergent Chemoenzymatic Synthesis of O-GalNAc Rare Cores 5, 7, 8 and Their Sialylated Forms Madhusudhan Reddy Gadi, Congcong Chen, Shumin Bao, Shuaishuai Wang, Yuxi Guo, Jinghua Han, Weidong Xiao and Lei Li Abstract All O-GalNAc glycans are derived from 8 cores with 2 or 3 monosaccharides linked via α- or β-glycosidic bonds.
Association of the interaction between mosaic chromosomal alterations and polygenic risk score with the risk of lung cancer: an array-based case-control association and prospective cohort study
State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China Department of Epidemiology, Centre for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Centre for Cancer Medicine, Nanjing Medical University, Nanjing, China State Key Laboratory of Reproductive Medicine, The Affiliated Suzhou Hospital of Nanjing Medical...
“Breathing” organic cation to stabilize multiple structures in low-dimensional Ge-, Sn-, and Pb-based hybrid iodide perovskites
“Breathing” organic cation to stabilize multiple structures in low-dimensional Ge-, Sn-, and Pb-based hybrid iodide perovskites Congcong Chen, Emily E Morgan, Yang Liu, Jian Chen, Ram Seshadri and Lingling Mao Abstract Low-dimensional hybrid inorganic–organic perovskites are candidates for stable optoelectronic devices. The dimensionality of these perovskites depends largely on the organic and inorganic compositions, as well as the synthetic conditions.
Occupancy Grid-Based AUV SLAM Method with Forward-Looking Sonar
Open AccessArticle by Xiaokai Mu 1,2,*, Guan Yue 1, Nan Zhou 2 and Congcong Chen 1 1 Science and Technology on Underwater Vehicle Technology Laboratory, Harbin Engineering University, Harbin 150001, China 2 Qingdao Innovation and Development Center, Harbin Engineering University, Qingdao 266000, China * Author to whom correspondence should be addressed.
Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
Abstract O-GalNAc glycans (or mucin O-glycans) play pivotal roles in diverse biological and pathological processes, including tumor growth and progression. Structurally defined O-GalNAc glycans are essential for functional studies but synthetic challenges and their inherent structural diversity and complexity have limited access to these compounds. Herein, we report an efficient and robust chemoenzymatic modular assembly (CEMA) strategy to construct structurally diverse O-GalNAc glycans.
Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives
Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives† Congcong Chen,abc Shuaishuai Wang, d Madhusudhan Reddy Gadi, d He Zhu,d Fei Liu,ac Chang-Cheng Liu,*be Lei Li, *d Fengshan Wang,*ab Peixue Ling*ac and Hongzhi Cao *be Author affiliations * Corresponding authors a School of Pharmaceutical Sciences, Key Laboratory of Chemical Biology (Ministry of Education), Cheeloo College of Medicine, Shandong University, Jinan 250012, China E-mail: fswang@sdu.edu.cn b...
Correction: Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
There is an error in the fifth sentence of the Abstract. The correct sentence is: Although 5α-dihydrotestosterone (DHT) treatment alone did not induce cell death, co-treatment of HPr-1AR cells with DHT and an apoptosis inducer, such as staurosporine (STS), TNFα, or hydrogen peroxide, synergistically increased cell death in comparison to treatment with each apoptosis inducer by itself. There are a number of errors in the third paragraph of the Introduction.
Machine‐Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
Frontispiece: Machine‐Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer
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Frontispiece: Machine‐Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer
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Machine Driven Enzymatic Oligosaccharide Synthesis by a Peptide Synthesizer
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
Facile Chemoenzymatic Synthesis of O‐Mannosyl Glycans
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
Facile Chemoenzymatic Synthesis of O‐Mannosyl Glycans
Department of Chemistry & Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA, USAThese authors contributed equally to this work, and are listed in alphabetical order by last name.Search for more papers by this author
Facile Chemoenzymatic Synthesis of O‐Mannosyl Glycans
Forgot your password? Enter your email address below. If your address has been previously registered, you will receive an email with instructions on how to reset your password. If you don't receive an email, you should register as a new user Please check your email for your password reset instructions.
Facile Chemoenzymatic Synthesis of O‐Mannosyl Glycans
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
Androgen receptor (AR) signaling is crucial to the development and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies. The mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells have been investigated in human and rodent adult prostate.
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