Corvin D. Arveseth on Muck Rack

Corvin D. Arveseth

As seen in: Nature, PLOS Biology
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Articles

Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway

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By William Steiner, Nathan Iverson, Guibing Liu, Varun Venkatakrishnan, Jian Wu, Tomasz Maciej Stepniewski, Ju-Fen Zhu, Annabel Lee, Isaac Nelson, Daniela Bertinetti, Corvin D. Arveseth, Gerald Tan Verified, Paul Spaltenstein, Jiewei Xu, Ruth Hüttenhain, Michael Kay Verified, Friedrich W. Herberg, Erhu Cao, Jana Selent, Ganesh S. Anand, Susan Taylor, Benjamin Myers, Zachary Michaelson, Jan W. Bröckel, Jessica G. H. Bruystens, Roland L. Dunbrack Jr.
| Nature Verified
Abstract The Hedgehog (Hh) pathway is fundamental to embryogenesis, tissue homeostasis and cancer. Hh signals are transduced through an unusual mechanism; upon agonist-induced phosphorylation, the noncanonical G-protein-coupled receptor (GPCR) Smoothened (SMO) binds the protein kinase A (PKA) catalytic subunit (PKA-C) and physically blocks its enzymatic activity.
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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction - Nature Structural & Molecular Biology

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By Corvin D. Arveseth, Daniela Bertinetti, Gianluigi Veglia, Susan Taylor, Jacob L. Capener, Friedrich W. Herberg
| Nature Verified
Abstract The Hedgehog (Hh) cascade is central to development, tissue homeostasis and cancer. A pivotal step in Hh signal transduction is the activation of glioma-associated (GLI) transcription factors by the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO). How SMO activates GLI remains unclear.
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Smoothened transduces hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

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By Danielle Hedeen, Corvin D. Arveseth, John T. Happ, Ju-Fen Zhu
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Corvin D. Arveseth , John T. Happ , Danielle S. Hedeen , Ju-Fen Zhu , Jacob L. Capener, Dana Klatt Shaw, Ishan Deshpande, Jiahao Liang, Jiewei Xu, Sara L. Stubben, Isaac B. Nelson, Madison F. Walker, Kouki Kawakami, Asuka Inoue, Nevan J. Krogan, David J. Grunwald, Ruth Hüttenhain, Aashish Manglik, [ ... ], Benjamin R. Myers [ view all ] [ view less ] Corvin D. Arveseth, John T. Happ, Danielle S. Hedeen, Ju-Fen Zhu, Jacob L.
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