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Articles by Cun Wang
A prelimbic cortex-lateral hypothalamus circuit regulates acquisition of alprazolam-induced conditioned place preference in male mice
Abstract Alprazolam (Alp), a high-potency benzodiazepine, poses a significant risk of abuse and addiction, yet the precise mechanisms underlying Alp-associated reward memory remain poorly defined. Here, we first established that administration of Alp at 10 mg/kg reliably induces conditioned place preference (CPP) in male mice. Our results indicated that prelimbic cortex (PrL) CaMKⅡα neurons were hyperactive in Alp-trained mice.
GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice
Abstract GATA-binding protein 3 (GATA3), a member of the GATA transcription factor family crucial for cellular development and differentiation, is normally expressed at low levels in mature neurons. However, its pathophysiological role in the brain remains poorly understood. Here, we report that GATA3 is involved in the mechanisms underlying chronic stress-induced depressive-like behaviors.
XPO1 inhibition induces NCOR1-Dependent oxidative stress to suppress hepatocellular carcinoma
Keywords hepatocellular carcinoma drug repurposing combination therapy oxidative stress XPO1 Get full text access Log in, subscribe or purchase for full access. References 1. Sung, H. ∙ Ferlay, J. ∙ Siegel, R.L. ... Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries CA Cancer J. Clin. 2021; 71:209-249 2. Liu, D. ∙ Song, T. Advances in neoadjuvant therapy for hepatocellular carcinoma Holist. Integ. Oncol. 2025; 4:37 3. Yang, C. ∙ Zhang, H.
Targeting tumor-intrinsic STK40 induces immune vulnerability and drives T cell reinvigoration
Keywords hepatocellular carcinoma CRISPR screening STK40 anti-tumor immunity immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Llovet, J.M. ∙ Castet, F. ∙ Heikenwalder, M. ... Immunotherapies for hepatocellular carcinoma Nat. Rev. Clin. Oncol. 2022; 19:151-172 2. Sangro, B. ∙ Sarobe, P. ∙ Hervás-Stubbs, S. ... Advances in immunotherapy for hepatocellular carcinoma Nat. Rev. Gastroenterol. Hepatol. 2021; 18:525-543 3. Wang, Z. ∙ Wang, Y. ∙ Gao, P. ...
Coptis Root-Derived Hierarchical Carbon-Supported Ag Nanoparticles for Efficient and Recyclable Alkyne Halogenation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma
Keywords hepatocellular carcinoma oxidative phosphorylation IACS-010759 DYRK1A TGF-β signaling Get full text access Log in, subscribe or purchase for full access. References 1. Warburg, O. On the origin of cancer cells Science. 1956; 123:309-314 2. Lissanu Deribe, Y. ∙ Sun, Y. ∙ Terranova, C. ... Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer Nat. Med. 2018; 24:1047-1057 3. Molina, J.R. ∙ Sun, Y. ∙ Protopopova, M. ...
On-the-fly optimization of the lattice parameters with a symmetry constraint for high-throughput calculation
On-the-fly optimization of the lattice parameters with a symmetry constraint for high-throughput calculation We developed AxisOpt, a program that aims for selective cell shape relaxation, with a symmetry constraint integrated into the Vienna ab initio simulation package (VASP). The program has wide applicability for two-dimensional (2D) and three-dimensional (3D) materials.
Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
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1State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute & Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2Immune Regulation in Cancer Group, German Cancer Research Center (DKFZ), Heidelberg, Germany 3Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Medical...
By Chen Yang, Haigang Geng, Xupeng Yang, Shuyi Ji, Zhicheng Liu, Hao Feng, Qian Li, Tangansu Zhang, Sisi Zhang, Xuhui Ma, Nuo Xu, Yuhan Xia, Hongye Wang, Beiping Miao, Lei Xu, Hui Wang, Ying Cao, Botai Li, Lili Zhu, Xiangyu Tang, Haoyu Zhang, Chunchao Zhu, Zhao Huang, Haiyan Hu, Xiaoping Chen, Shengxian Yuan, Guangzhi Jin, René Bernards, Chong Sun, Quan Zheng, Wenxin Qin, Qiang Gao, Cun Wang, Chuchen Zhu, Chune Yu, Shangce Du, Chao Leng
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Separations | Free Full-Text | An Extraction Process Based on the Collaborative Extraction of Coptis chinensis Franch. Phytoconstituents Using a Deep Eutectic Solvent and an Organic Solvent
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Sensitive fluorescence assay of chloramphenicol coupled with two-level isothermal amplification using a self-powered catalyzed hairpin assembly and entropy-driven circuit
Sensitive fluorescence assay of chloramphenicol coupled with two-level isothermal amplification using a self-powered catalyzed hairpin assembly and entropy-driven circuit† Two levels of nucleic acids-based isothermal amplification normally require a long reaction time due to the low concentration of catalyst, which limits its practical application.
Harnessing Ash for Sustainable CO2 Absorption: Current Strategies and Future Prospects
This review explores the potential of using different types of ash, namely fly ash, biomass ash, and coal ash etc., as mediums for CO2 capture and sequestration. The diverse origins of these ash types—municipal waste, organic biomass, and coal combustion—impart unique physicochemical properties that influence their suitability and efficiency in CO2 absorption.
Distributed Fault Diagnosis via Iterative Learning for Partial Differential Multi-Agent Systems with Actuators
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Nonlinear Modeling and Vibration Response Analysis of a Dual-Rotor System with an Inter-Shaft Graphite Seal
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Synthesis and Mechanochromic Response of a Large Sterically Hindered Alkynyl-Protected Au22 Nanocluster
Download Hi-Res ImageDownload to MS-PowerPointCite This:Organometallics 2023, XXXX, XXX CCDC 2249727 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
Synthesis and Mechanochromic Response of a Large Sterically Hindered Alkynyl-Protected Au22 Nanocluster
Download Hi-Res ImageDownload to MS-PowerPointCite This:Organometallics 2023, XXXX, XXX CCDC 2249727 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
The CBL1/9-CIPK1 calcium sensor negatively regulates drought stress by phosphorylating the PYLs ABA receptor - Nature Communications
Abstract The stress hormone, Abscisic acid (ABA), is crucial for plants to respond to changes in their environment. It triggers changes in cytoplasmic Ca2+ levels, which activate plant responses to external stresses. However, how Ca2+ sensing and signaling feeds back into ABA signaling is not well understood.
In Vitro Investigation of the Anticancer Activity of Peucedanum praeruptorum Dunn Extract on HepG2 Human Hepatoma Cells
The anticancer activity of Peucedanum praeruptorum Dunn extract (PPDE) was investigated in vitro in the HepG2 human hepatoma cell line and compared to normal human liver cells (L02 cells). The effect of the PPDE on the proliferation of the cells was measured by MTT assays, and the levels of enzymes and small molecules implicated in oxidative stress regulation were measured using specific reagent kits.
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
Abstract The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting glutamine addiction using the glutaminase inhibitor CB-839 as monotherapy had a very limited anticancer effect, even against the most glutamine addicted human liver cancer cells.
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma Cun Wang1,2, Hui Wang2, Cor Lieftink1, Aimee du Chatinier1, Dongmei Gao3, Guangzhi Jin4, Haojie Jin1,2, Roderick L Beijersbergen1, Wenxin Qin2, René Bernards1 1 Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands 2 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai...
A Novel Signal Self-enhancement Photoelectrochemical Immunosensor without Addition Sacrificial Agent in Solution Based on Ag2S/CuS/α-Fe2O3 n-p-n Heterostructure Films
A Novel Signal Self-enhancement Photoelectrochemical Immunosensor without Addition Sacrificial Agent in Solution Based on Ag2S/CuS/α-Fe2O3 n-p-n Heterostructure Films You have access to this article Please wait while we load your content... Something went wrong. Try again?
Inducing and exploiting vulnerabilities for the treatment of liver cancer
Abstract Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatocellular carcinoma3. The induction of senescence may represent a strategy for the treatment of cancer, especially when combined with a second drug that selectively eliminates senescent cancer cells (senolysis)4,5.
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma Cun Wang1,2, Hui Wang2, Cor Lieftink1, Aimee du Chatinier1, Dongmei Gao3, Guangzhi Jin4, Haojie Jin1,2, Roderick L Beijersbergen1, Wenxin Qin2, René Bernards1 1Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands 2State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao...
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma Cun Wang1,2, Hui Wang2, Cor Lieftink1, Aimee du Chatinier1, Dongmei Gao3, Guangzhi Jin4, Haojie Jin1,2, Roderick L Beijersbergen1, Wenxin Qin2, René Bernards1 1Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands 2State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao...
High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer
Drug resistance is the biggest obstacle to the effective treatment of cancer. When patients fail first line treatment, they are often offered second and even third line therapies in the hope to provoke a response with a drug that is mechanistically distinct from the first line therapy. In general, such subsequent therapies are less effective than first line therapy. To address these issues, we explore the induction of senescence as a potential anti-cancer strategy.
Selective Hydrogenation of Levulinic Acid to γ-valerolactone using in-situ generated Ruthenium Nanoparticles derived from Ru-NHC complexes
The hydrogenation of levulinic acid (LA) to -valerolactone (GVL) was studied by using mono- and bidentate p-cymene ruthenium(II) N-heterocyclic carbene (NHC) complexes as catalysts precursors. In water, all complexes were found to be reduced in-situ to form ruthenium nanoparticles (RuNPs) with a high hydrogenation activity.
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