Abstract To achieve the goal of “eliminating viral hepatitis as a public health threat by 2030” proposed by the World Health Organization, we explore the spatio-temporal dynamics of hepatitis incidence in China to provide reference for research, prevention, and control of hepatitis and other public health diseases. Local Indicators of Spatial Association (LISA) and Mann-Kendall (MK) trend tests were used to analyze the spatial-temporal variation of hepatitis incidence in China from 2012 to 2019.