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Dadao An

As seen in: Nature, Cell Press
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Articles

Histamine H 2 receptor in substantia nigra pars reticulata parvalbumin positive neurons mediates risk-taking behavior

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By Dadao An, Lingyan Zheng, Jinjin Zhu, Zonghan Liu, Zhengyi Xu, Yanrong Zheng, Yi Wang, Weiwei Hu, Zhong Chen
| Nature Verified
Abstract Risk-taking is frequently observed in psychiatric conditions such as attention-deficit hyperactivity disorder, yet the neuronal mechanisms underlying this behavior remain unclear. Here, we show that histamine H2 receptor (H2R) in parvalbumin-positive neurons (PV+) of the substantia nigra pars reticulata (SNr) bidirectionally regulates risk-taking behaviors. Dysfunction of superior colliculus-projecting SNr PV+ neurons contributes to the increased risk-taking caused by H2R deficiency.
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Deficiency of histamine H2 receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention

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By Dadao An, Yi You, Qianyi Ma, Zhengyi Xu, Zonghan Liu, Ruichu Liao, Han Chen, Yiquan Wang, Yi Wang, Haibin Dai, Haohong Li, Lei Jiang, Zhong Chen, Weiwei Hu
| Cell Press Verified
Keywords histamine H2 receptor attention deficit hyperactivity disorder substantia nigra pars reticulata parvalbumin-positive neuron substantia nigra pars compacta intermediate layers of superior colliculus histamine dopaminergic neurons Get full text access Log in, subscribe or purchase for full access. References 1. Biederman, J. Attention-deficit/hyperactivity disorder: a selective overview Biol. Psychiatry. 2005; 57:1215-1220 2. Thapar, A. ∙ Cooper, M.
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