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Damon Rideaux

As seen in: Cell Press, Cell Reports
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Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface

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By Ivan Osokine, Damon Rideaux, Johan Siewiera
| Cell Reports Verified
Highlights • EZH2 prevents implantation from triggering wound-healing responses in the uterus • EZH2 prevents wound healing in the uterus by suppressing TGF-β activity • PRC2-generated H3K27me3 marks transcriptionally silence TGF-β target genes • Derepressed wound-healing responses in the uterus lead to pregnancy failure Summary A little-appreciated feature of early pregnancy is that embryo implantation and placental outgrowth do not evoke wound-healing responses in the decidua, the...
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By Geschrieben von, Damon Rideaux
| outlookohio.com
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