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Daniel He

As seen in: Medium, Nature, PLOS ONE, The Epoch Times, Cell Press, Michelin, Michelin Guide, Journal of Virology, Daily Northwestern, Wevolver
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Articles

PAWR augments anti-RNA viral innate immunity by promoting the PIM2-XBP1s-RIG-I signaling axis

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By Peili Hou, Xiaonan Sun, Hongchao Zhu, Yueyue Feng, Rui Li, Xiaoyun Wang, Fuzhen Zhang, Jun Wang, Yuanyuan Han, Daniel He, Hongmei Wang, Hongbin He
| Nature Verified
Abstract PRKC Apoptosis WT1 Regulator (PAWR) has been implicated in tumorigenesis. However, its role in antiviral innate immunity remains unexplored. Here, we demonstrate that PAWR transcriptionally upregulates RIG-I expression through the transcription factor X-box binding protein 1 (XBP1). Mechanistically, PAWR potentiates the ATF6/IRE1-XBP1 pathway to upregulate spliced form XBP1 (XBP1s) and simultaneously promotes PIM2-mediated phosphorylation of XBP1s at Ser68.
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Visit These Unique Restaurants You Can Only Find in California

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By Daniel He
| Michelin Guide
When it comes to food, there’s something that makes California special. Maybe it’s the incredibly fresh produce, the seasonality of ingredients, the farm-to-table ethos that originated in the state. “From Napa wines and Central Valley fruits to seafood from the California coast, chefs have access to produce that is rare or unavailable in other states,” says JuMi Pitiwartarlai, chef and co-owner of Sovereign in San Diego.
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If determinism is true, do we have free will and moral responsibility?

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By Daniel He
| Medium
If determinism is true, do we have free will and moral responsibility? When we reflect on our past actions — “Was I wrong to say that?” or “Should I have treated that person differently?” — we typically assume we made these choices, or that there were alternative options, and are responsible for our decisions. This belief in free will shapes how we judge behaviour and define moral responsibility.
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