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Articles by Daniel Hippe
ctDNA or Merkel Virus Antibodies for Surveillance of Merkel Cell Carcinoma Recurrence
ctDNA or Merkel Virus Antibodies for Surveillance of Merkel Cell Carcinoma Recurrence Key Points Question When monitoring for recurrent Merkel cell carcinoma, which blood-based test is more accurate: circulating tumor DNA (ctDNA) or Merkel cell polyomavirus antibody testing?
Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer
Abstract Small cell lung cancer (SCLC) responds exceptionally well to cytotoxic chemotherapy. However, relapse with the emergence of chemoresistant disease is rapid and accompanied by poor treatment outcomes. To understand the genetic basis of chemoresistance in SCLC, we apply in vivo CRISPR deletion screening to patient-derived xenograft (PDX) models. Top screen hits include genes encoding components of the transcriptional co-activator SAGA (Spt-Ada-Gcn5 acetyltransferase) complex.
Minimal Efficacy of Single-Agent Anti-PD(L)1 Rechallenge in Immunotherapy-Refractory Merkel Cell Carcinoma: A Retrospective Cohort Study of 16 Patients
You are already at the latest version Background/Objectives: Anti-PD(L)1 immune checkpoint inhibitors (ICI) provide durable responses in nearly 50% of patients with advanced Merkel cell carcinoma (MCC). However, for those progressing on first-line ICI, optimal subsequent therapy remains unclear. Although presumed to have limited benefit, the efficacy of rechallenge with anti-PD(L)1 alone has not been formally reported.
The Role of Estrogen Receptor-Targeted PET with 16α-18F-Fluoro-17β-Estradiol in Predicting Response to Endocrine Therapies in Metastatic Breast Cancer: A Metaanalysis | Journal of Nuclear Medicine
DISCUSSION This metaanalysis reviewed published studies to determine the effectiveness of [18F]FES PET in predicting response to ET in patients with mBC. Although higher baseline [18F]FES uptake was associated with ET response, the most compelling finding emerged from the analysis of interlesional heterogeneity. Specifically, patients with heterogeneous [18F]FES uptake (defined as a mix of FES+ and FES− lesions) consistently experienced shorter PFS than those with homogeneous FES+ disease.
Polyomavirus Antibodies for Merkel Cell Carcinoma Recurrence Detection
Ayuda Buscar en la ayuda Buscar en la ayuda Polyomavirus Antibodies for Merkel Cell Carcinoma Recurrence Detection Autores: Lindsay Gunnell, Daniel S. Hippe, Song Y. Park, Alex Fu, Tomoko Akaike, Kristina Lachance, Kelsey Cahill, Coley Doolittle Amieva, Paul Nghiem Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 161, Nº. 11, 2025, págs.
Plaque-Reporting and Data System Related to Cerebrovascular Event Risk with Mild/Moderate Stenosis: A Chinese Atherosclerosis Risk Evaluation II Study
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Polyomavirus Antibodies for Merkel Cell Carcinoma Recurrence Detection
Ayuda Buscar en la ayuda Buscar en la ayuda Polyomavirus Antibodies for Merkel Cell Carcinoma Recurrence Detection Gunnell, Lindsay [2] ; Hippe, Daniel S. [1] ; Park, Song Youn [2] [1] Rocky Mountain MS Center [2] MD Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 161, Nº. 8, 2025, págs. 10-19 Idioma: inglés Enlaces Texto completo Resumen Importance Merkel cell carcinoma (MCC) is typically caused by the Merkel cell polyomavirus (MCPyV) and recurs in 40% of patients.
Immunotherapy response in immunosuppressed patients with Merkel cell carcinoma: analysis of 183 patients
Immune checkpoint inhibitors (ICIs) have greatly improved outcomes for immunocompetent patients with advanced Merkel cell carcinoma (MCC). However, ICI efficacy in immunosuppressed patients remains unclear. Immunosuppressed MCC patients benefited from ICIs, though they faced higher risks of disease progression and mortality compared with immunocompetent patients, with chronic lymphocytic leukaemia patients showing particularly low response rates.
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity
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Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis
Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis | Dermatology | JAMA Dermatology | JAMA Network [Skip to Navigation] Figure 1. Comparison of Merkel Cell Carcinoma (MCC) Recurrence and Survival Rates Between the Present Cohort and Existing Literature Figure 2.
Computed tomography angiography findings predictive of post-intervention vasospasm in patients with aneurysmal subarachnoid hemorrhage
© 2021 The Authors.
Comparing Automatic and Manual Measures of Parent-Infant Conversational Turns: A Word of Caution
Abstract The Language ENvironment Analysis system (LENA) records children’s language environment and provides an automatic estimate of adult–child conversational turn count (CTC). The present study compares LENA’s CTC estimate to manually coded CTC on a sample of 70 English‐speaking infants recorded longitudinally at 6, 10, 14, 18, and 24 months of age.
Comparison of Time-of-Flight MR angiography and intracranial vessel wall MRI for luminal measurements relative to CT angiography
To assess whether intracranial vessel wall MRI (IVW) luminal measurements are more accurate than non-contrast 3D-TOF-MRA measurements for intracranial atherosclerotic stenosis, relative to CTA. Consecutive patients with non-calcified intracranial atherosclerotic stenosis seen on CTA, who had non-contrast 3D-TOF-MRA and IVW performed between 1/1/2013 and 4/20/2014 were selected, and images with stenosis were pre-selected by a single independent rater.
Segmented quantitative diffusion tensor imaging evaluation of acute traumatic cervical spinal cord injury
© 2020 The Authors.
Emergency Radiology: An Underappreciated Source of Liability Risk
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Diagnostic errors are the primary source of liability risk in radiology [1]. Radiologists are in the midrange of subspecialists with respect to both the frequency of claims and the cost of settlements [1,2]. Even so, the average radiologist is involved with the medicolegal system for a substantial portion of her career [3].
Environmental Factors Predictive of No-Show Visits in Radiology: Observations of Three Million Outpatient Imaging Visits Over 16 Years
Abstract Purpose To evaluate the impact of environmental and socioeconomic factors on outpatient cancellations and “no-show visits” (NSVs) in radiology. Materials and Methods We conducted a retrospective analysis by collecting environmental factor data related to outpatient radiology visits occurring between 2000 and 2015 at our multihospital academic institution.
MRI Radiomic Features Are Independently Associated with Overall Survival in Soft Tissue Sarcoma
INTRODUCTION Soft tissue sarcomas (STS) exhibit a wide range of behavior, from indolent tumors with long patient survival to highly aggressive disease that can be rapidly fatal. Surgical resection is the cornerstone of treatment for localized disease, and the addition of radiotherapy (RT) and chemotherapy have allowed for limb-sparing surgery and improved local and distant control (Sarcoma Meta-analysis 2000, Pisters, Pollock et al. 2007).
Added Value of Vessel Wall Magnetic Resonance Imaging in the Differentiation of Moyamoya Vasculopathies in a Non-Asian Cohort
Background and Purpose—Although studies have evaluated the differential imaging of moyamoya disease and atherosclerosis, none have investigated the added value of vessel wall magnetic resonance imaging (MRI). This study evaluates the added diagnostic value of vessel wall MRI in differentiating moyamoya disease, atherosclerotic-moyamoya syndrome (A-MMS), and vasculitic-MMS (V-MMS) with a multicontrast protocol.
Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes
Results—Twenty-one cases of atherosclerosis (intracranial atherosclerotic disease [ICAD]), 4 of reversible cerebral vasoconstriction syndrome, and 4 of vasculitis were identified, with a total of 118 stenotic lesions (81 ICAD, 22 reversible cerebral vasoconstriction syndrome, and 15 vasculitic lesions).
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