Daniel Hu
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Articles by Daniel Hu
Caso de estudio: Exposición ocupacional masiva a fentanilo líquido por vía cutánea
El fentanilo sigue siendo un tema candente en el mundo de los SEM, particularmente en el contexto del riesgo de exposición ocupacional para los primeros respondedores, un área donde continúa habiendo una significativa percepción errónea. Muchos primeros respondedores, creen que incluso la cantidad más pequeña de fentanilo, ya sea por inhalación o por contacto, puede causar toxicidad o incluso la muerte.
How Document Review Software Is Changing Legal Practice
Daniel Hu: CTO & Co-Founder of Fileread. Software engineer (CS & Math). Tech visionary reimagining legaltech. getty Walk into a major litigation department today and you’ll notice something odd—it’s quiet. No chaos. No associates buried under mountains of paper. Just attorneys at computers, occasionally huddling to discuss strategy instead of logistics. This isn’t because there’s less work. It’s because the work has fundamentally changed.
The Next Chapter: Five AI Trends Reshaping Legal Document Review
Daniel Hu: CEO & Co-Founder of Fileread. Software engineer (CS & Math). Tech visionary reimagining legaltech. getty Law has always been drowning in paperwork. From ancient legal codices to today's digital repositories, attorneys have traditionally spent countless hours reviewing documents. Now, revolutionary advances in artificial intelligence are fundamentally transforming this aspect of legal practice. These aren't minor upgrades to existing systems.
Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway - Nature Communications
Abstract Concerted migration of basal stem cells (BCs) in the airway, also known as epithelial fluidization, has been implicated in epithelial repair after injury. How BC migration is regulated, and how it influences the success of epithelial repair, remains unclear. Here we have identified non-canonical Wnt signaling through Ptk7, Fzd7, and YAP as a critical regulator of BC migration in the mouse trachea.
One-Pot Quantitation of Mycobacterial N-terminal Protein Acetylation Peptidoforms and Proteome
Abstract Isotopic labeling of proteins for quantitative proteomics is a popular technique to increase sample throughput and provide improved accuracy and precision for relative or absolute quantitation between samples. Derivatives of this technique are used to label protein and peptide N-termini for selective enrichment and analysis. We previously reported on a method to enrich and quantify protein N-terminal acetylation in model-system and pathogenic mycobacteria.
Mixologist extraordinaire K.T. unveils an entirely new experience at Sora Bar
Meet mixologist extraordinaire LAM KA TSUN, known as ‘K.T.’, the former Beverage Manager of DarkSide that was #9 on Asia’s 50 Best Bars, unveils an entirely new experience at Sora Bar. Lam Ka Tsun, or K.T.’s remarkable cocktail journey, began at the award-winning Zuma Restaurant in Hong Kong, where he met his mentor and idol, Arkadiusz Rybak—a revered figure in the global hospitality and cocktail community.
N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum
Abstract Phagosomal lysis is a key aspect of mycobacterial infection of host macrophages. Acetylation is a protein modification mediated enzymatically by N-acetyltransferases (NATs) that impacts bacterial pathogenesis and physiology. To identify NATs required for lytic activity, we leveraged Mycobacterium marinum, a nontubercular pathogen and an estab-lished model for M. tuberculosis. M. marinum hemolysis is a proxy for phagolytic activity. We generated M.
N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum
Abstract Mycobacterial pathogens, including M. tuberculosis, the cause of human tuberculosis, and the non-tubercular species, M. marinum exhibit lytic activity in the host phagosome that is essential for disease. Acetylation is a conserved protein modification that is mediated enzymatically by N-acetyltransferases (NATs). NATs acetylate protein Nɑ-termini, lysine residues, and small mole-cules like antibiotics to alter bacterial physiology and pathogenesis.
The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in Mycobacterium marinum
Abstract The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 system-1) is a conserved protein secretion system required for mycobacterial pathogenesis (1, 2). Previous studies revealed that mycobacterial strains lacking the outer lipid PDIM have impaired ESX-1 function during laboratory growth and infection (3-5).
Glaukos Technologies Featured in Numerous Scientific Abstracts at the 2023 American Academy of Ophthalmology Annual Meeting
Glaukos Technologies Featured in Numerous Scientific Abstracts at the 2023 American Academy of Ophthalmology Annual Meeting Glaukos Corporation (NYSE: GKOS), an ophthalmic medical technology and pharmaceutical company focused on novel therapies for the treatment of glaucoma, corneal disorders and retinal diseases, announced today that its technologies will be featured in various scientific programming at the American Academy of Ophthalmology (AAO) annual meeting, being held November 3-6, 2023...
Glaukos Technologies Featured in Numerous Scientific Abstracts at the 2023 American Academy of Ophthalmology Annual Meeting
Glaukos announced that its technologies will be featured in various scientific programming at the American Academy of Ophthalmology (AAO) annual meeting, being held November 3-6, 2023 in San Francisco. Glaukos will be exhibiting onsite at booth #1630. Key Glaucoma Presentations: Saturday, November 4, 2023, at 10:00 – 10:30 a.m. PT Jason Bacharach, MD IOP at Month 3 with Travoprost Intraocular Implant vs. IOP at Screening While on Prostaglandin Analog Monotherapy Key Glaucoma Posters: Mark J.
family as self portrait [narrative]
I. KNOWN FACTS ABOUT MY FATHER He grew up in a village around Wuxi. He has a brother whom I have never met. He says that he cannot handle spicy food anymore after an incident in his youth when he passed out while eating spicy huo guo in Sichuan. He is afflicted with gout. He loves gardening for the simple joy of clipping stalks of jiu cai. He strains soybeans over a colander every morning to make soy milk for my mother. He is fascinated by feng shui and the movement of invisible energy across space.
Seven Lakes Basin and the High Divide Loop
The High Divide Loop (also known as the 7 Lakes Basin) is, in my mind, the most beautiful hike in all of Washington state. Nestled deep in Olympic National Park, this trail comes with spectacular views and is teeming with wildlife. If you’re looking at a map of the United States, touch your finger to the most northwestern point in Washington state, and you’ll be fairly close to identifying its location.
Seizures Following Self-Medication With Colloidal Silver: A Case Report
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How much does backpacking really cost? Original
One of the great things about backpacking is that going out into the backcountry costs essentially nothing – I often remark that as far as activities cost, backpacking is free! On the other hand, backpacking gear can cost a person quite a bit of money. I recall years ago that a friend expressed an interest in backpacking, and asked how much he might want to budget for gear.
Immune-Related Long Non-Coding RNA Signatures for Tongue Squamous Cell Carcinoma
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Immune-Related Long Non-Coding RNA Signatures for Tongue Squamous Cell Carcinoma
1. Introduction Tongue squamous cell carcinoma (TSCC) is the most common malignancy of the oral cavity [1,2]. A recent study suggested that about 45% of all oral cavity cancers were TSCCs [3]. TSCC generally affects the older age group of patients (e.g., 60 to 80 years of age) who have been exposed to tobacco and/or drinking for certain period of time. However, recent studies indicate that there has been an increasing incidence of TSCC in the younger age group [4,5,6].
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
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chinese summer, american camp [narrative]
Dear Pastor B, Of you I remember almost nothing. I remember a speech about divine grace you gave before we watched Kung Fu Panda at Bible camp. I remember your spindly fingers and the bumpy blue-gray veins that pulsed down your forearms, and the way you walked with a thumping arrhythmic gait. I remember the call-and-response you used to get us to quiet down: You sang out bum bum buh-dum bum and waited for us to sing back bum bum! I remember your white hair and your hawkish blue eyes.
Miniprep assisted proteomics (MAP) for rapid proteomics sample preparation
Miniprep assisted proteomics (MAP) for rapid proteomics sample preparation† Complete enzymatic digestion of proteins for bottom-up proteomics is substantially improved by use of detergents for denaturation and solubilization. Detergents however, are incompatible with many proteases and highly detrimental to LC-MS/MS. Recently; filter-based methods have seen wide use due to their capacity to remove detergents and harmful reagents prior to digestion and mass spectrometric analysis.
Miniprep assisted proteomics (MAP) for rapid proteomics sample preparation
Miniprep assisted proteomics (MAP) for rapid proteomics sample preparation† C. Bruce Mousseau, a Camille A. Pierre,a Daniel D. Hu a and Matthew M. Champion *ab Abstract Complete enzymatic digestion of proteins for bottom-up proteomics is substantially improved by use of detergents for denaturation and solubilization. Detergents however, are incompatible with many proteases and highly detrimental to LC-MS/MS.
bruce lee, messiah [narrative]
I. FOURS Scripture teaches us this: All Creation is made in the image of Bruce Lee. The basic structure of Bruce Lee is the quadripartite structure: two arms and two legs, four instruments with which He might inflict violence.
to: the dictionary xoxo [feature]
DANIEL HU (noun) (1) the hipster poser who will spend the next ~1600 words creaming his pants over the idea of words My Latin teacher in high school made me love the dictionary, which is a weird-ass book to claim to love. She loved to connect English words to their Latin roots, and she spent huge portions of class time tracing the words on our weekly vocabulary lists to their English counterparts.
Bearvault BV500 Review
This is a preview of a member exclusive premium article. Introduction The BearVault BV500 (41 oz / 1.16 kg, MSRP $87.95) is an Interagency Grizzly Bear Committee (IGBC)-certified and Sierra Interagency Black Bear Group-approved bear canister meant for long-distance adventures. It fits up to 7 days of food for a single person (capacity 11.5 L / 700 cubic inches).
A GLOSSARY OF TERMS FOR 旦一 [narrative]
Preface: Your name is DANIEL HU. This is not a Chinese name. Your parents named you in Mandarin first: 旦一. This name has since been supplanted by DANIEL such that 旦一 is now your middle name instead. 旦一 is made up of very simple characters because your parents figured you might grow up to be too illiterate in Mandarin to recognize even your own name in writing. They chose a similar-sounding English name that would allow you to blend in with your peers.
Pharmacology 101: Thrombolytics for Acute Ischemic Stroke
On average someone in the United States has a stroke every 40 seconds.1 This dire statistic from the American Heart Association (AHA) represents the fact that every year approximately 795,000 Americans experience stroke, of which 87% are ischemic strokes.
Pharmacology 101: Kratom, Part 2
Kratom is advertised at a Manhattan cannabis dispensary. (Photo: Tdorante10/Wikimedia Commons) Find the first part of this series here. As mentioned in Part 1 of this series, the two main biologically active alkaloids in kratom are mitragynine and 7-hydroxymitragynine.1,2 Recall that pharmacokinetics describes the study of the time course of drug absorption, distribution, metabolism, and excretion.
Pharmacology 101: Kratom, Part 1
One survey published in Addiction in 2021 reported results showing that past-year kratom use in the adult US population was 0.8%. (Photo: Psychonaught/Wikimedia Commons) There’s a gas station I pass nearly every day that has a sandwich board advertising kratom for sale. It looks innocuous, just a simple sold here sign in big bold letters. But what is kratom?
Sunscreen for Hiking and Backpacking: Efficacy, Ingredient Safety, and Best Practices - Backpacking Light
Introduction Sunscreen for hiking and backpacking tends to take a back seat to other (more prominent) types of outdoor gear. While sunscreen use is prevalent in our society, there are basic facts about sunscreen that may not be known by the general public. The purpose of this article is to provide information to enable users to safely and effectively use sunscreen while adventuring. As a long-time hiker and backpacker, I’ve grown wary of the harmful effects of ultraviolet light.
The Hemodynamics of RSI: Ketamine vs. Etomidate
Rapid sequence intubation (RSI) is an emergency procedure frequently performed in the prehospital setting. Induction with sedating agents is an important step in this process. The use of etomidate for this purpose has long been a standard of practice.
Vargo ExoTi BOG Backpack Review
Introduction The Vargo ExoTi BOG backpack (2 pounds 9 ounces / 1.16 kg, MSRP $299.95) is a roll-top, external, titanium-framed backpack with a removable 40-liter 70 denier primary compartment. This article provides a review of the pack as well as an in-depth interview with the designer (Brian Vargo) about the design philosophy behind the pack. The Vargo ExoTi series is an interesting take on the ultralight external-frame concept.
Review of Colt’s Crisis by Tom Carroll
By Daniel Hu Colt’s Crisis, the first in a promised series of thrillers featuring protagonist Colt Garrett was published a couple months ago. I received a copy to review for The JOLT, and I found the book to be a fast-paced and enjoyable experience.
Helly Hansen Odin Minimalist 2.0 Jacket Review
Introduction The Helly Hansen Odin Minimalist 2.0 jacket (180 g / 6.35 oz, $220) is a lightweight 2.5 layer rain jacket featuring Helly Tech Professional fabric. It has a minimalist feature-set and a well-designed hood. Photo: Helly Hansen. About this Review This Limited Review is reflective of a testing period of 8 days in Eastern Washington in late October and early November.
Hot off the press: the definitive history of Thurston County
By Daniel Hu For residents of Olympia, Tumwater, and Lacey, there’s a new book that sheds light on the rich – and at times, tumultuous – history of Thurston County. Titled Thurston County: Water, Woods, and Prairies – Essays on the History of Washington’s Capital County, it’s a collection edited by Sandra A. Crowell and Shirley A. Stirling, capturing stories by a cast of all-star local historians.
City transportation engineering supervisor explains Henderson roundabout
By Daniel Hu for JOLT OLYMPIA –– If you drive down Henderson Boulevard regularly, you probably noticed a traffic circle that sprang up at the intersection of Henderson and Eskridge. Interestingly, it appears to be offset – drivers noticed they must curve around the roundabout when traveling north, but southbound traffic seems to be able to coast straight through. What’s the background to the construction of this traffic circle? Why was it placed? How much did it cost?
Wang
9 May 2020 Daniel Hu Intensive Care Medicine Wang Y. Lancet; Epub Ahead of Print. doi: https://doi.org/10.1016/S0140-6736(20)31022-9 Clinical Question In patients with severe COVID-19, does intravenous remdesivir, compared with placebo, improve the time to clinical improvement?
Emergency Medicine Pharmacist Market Perceptions: Emergency Medicine Residency Program Directors and Directors of Pharmacy
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Abstract Objective Graduating pharmacists are applying to postgraduate year one (PGY1) and postgraduate year two (PGY2) programs at a rate that is outpacing the number of programs available. Emergency department (ED) PGY2 programs are gaining in popularity and competitions is increasing for applicants.
New Bank Technologies Demand Fresh Approach to Product Development
Subscribe to The Financial Brand via email for FREE! Throughout history businesses have had to learn to adapt to new technologies or languish, and this holds true for banks and credit unions more than ever before. Today financial institutions confront an accelerated pace of change, rising consumer expectations, and the demands of an evolving workforce. Change is inevitable, under today’s circumstances and given the alternative.
Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity
Highlights • Spindles reorient from oblique to planar during growth, driving symmetric outcomes • Stress- and aging-mediated activation of JNK promotes planar spindles • JNK interacts with Wdr62 and represses Kif1a expression to promote planar spindles • Restoring oblique spindles in old flies extends lifespan Summary Tissue homeostasis depends on precise yet plastic regulation of stem cell daughter fates.
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